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Applications of toxicogenomics in sa...

Gollapudi, B. Bhaskar.

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Applications of toxicogenomics in safety evaluation and risk assessment

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Applications of toxicogenomics in safety evaluation and risk assessment/ edited by Darrell R. Boverhof, B. Bhaskar Gollapudi.
other author:	Gollapudi, B. Bhaskar.
Published:	Hoboken, N.J. :John Wiley & Sons, : c2011.,
Description:	1 online resource (xiii, 377 p.) :ill.
[NT 15003449]:	Toxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation--activities in Japan -- -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach.
Subject:	Genetic toxicology. -
Online resource:	http://onlinelibrary.wiley.com/book/10.1002/9781118001042
ISBN:	9781118001042 (electronic bk.)

Applications of toxicogenomics in safety evaluation and risk assessment
Applications of toxicogenomics in safety evaluation and risk assessment[electronic resource] /edited by Darrell R. Boverhof, B. Bhaskar Gollapudi. - Hoboken, N.J. :John Wiley & Sons,c2011. - 1 online resource (xiii, 377 p.) :ill.

Includes bibliographical references and index.

Toxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment--early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation--activities in Japan -- -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach.

"This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm"--Provided by publisher.

ISBN: 9781118001042 (electronic bk.)

Source: 10.1002/9781118001042Wiley InterSciencehttp://www3.interscience.wiley.comSubjects--Topical Terms:

783793
Genetic toxicology.
Index Terms--Genre/Form:

542853
Electronic books.

LC Class. No.: RA1224.3 / .B68 2011eb

Dewey Class. No.: 616/.042

National Library of Medicine Call No.: QV 38

Applications of toxicogenomics in safety evaluation and risk assessment
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245 0 0 $a Applications of toxicogenomics in safety evaluation and risk assessment $h [electronic resource] / $c edited by Darrell R. Boverhof, B. Bhaskar Gollapudi.
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520 # $a "This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm"--Provided by publisher.
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