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Development and assessment of analyt...

Praamsma, Meredith L.

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Development and assessment of analytical methods for monitoring current and historical exposures to manganese: Blood, urine, and teeth.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Development and assessment of analytical methods for monitoring current and historical exposures to manganese: Blood, urine, and teeth./
Author:	Praamsma, Meredith L.
Description:	320 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.
Contained By:	Dissertation Abstracts International74-10B(E).
Subject:	Environmental Health. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3566564
ISBN:	9781303178658

Development and assessment of analytical methods for monitoring current and historical exposures to manganese: Blood, urine, and teeth.
Praamsma, Meredith L.

Development and assessment of analytical methods for monitoring current and historical exposures to manganese: Blood, urine, and teeth. - 320 p.

Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.

Thesis (Ph.D.)--State University of New York at Albany, 2013.

Manganese, as an essential trace element, is a cofactor in numerous enzymes that aid in bone growth, cholesterol synthesis, and carbohydrate metabolism. Manganese can become toxic with overexposure, potentially leading to neurodegenerative effects and the disease manganism. Manganese concentrations in blood and urine have been widely used in monitoring current exposure and now there is interest in using manganese concentrations in teeth for monitoring historical exposure, especially in utero and in early childhood.

ISBN: 9781303178658Subjects--Topical Terms:

578282
Environmental Health.

Development and assessment of analytical methods for monitoring current and historical exposures to manganese: Blood, urine, and teeth.
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020 $a 9781303178658
035 $a (MiAaPQ)AAI3566564
035 $a AAI3566564
040 $a MiAaPQ $c MiAaPQ
100 1 $a Praamsma, Meredith L. $3 2106376
245 1 0 $a Development and assessment of analytical methods for monitoring current and historical exposures to manganese: Blood, urine, and teeth.
300 $a 320 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.
500 $a Adviser: Patrick Parsons.
502 $a Thesis (Ph.D.)--State University of New York at Albany, 2013.
520 $a Manganese, as an essential trace element, is a cofactor in numerous enzymes that aid in bone growth, cholesterol synthesis, and carbohydrate metabolism. Manganese can become toxic with overexposure, potentially leading to neurodegenerative effects and the disease manganism. Manganese concentrations in blood and urine have been widely used in monitoring current exposure and now there is interest in using manganese concentrations in teeth for monitoring historical exposure, especially in utero and in early childhood.
520 $a The primary objective of this study was to develop, validate, and compare methods for the determination of manganese in blood and urine using graphite furnace atomic absorption spectrometry (GFAAS), quadrupole-based (Q-) inductively coupled plasma mass spectrometry (ICP-MS), and sector field (SF-) ICP-MS. A secondary goal was to investigate the determination of manganese in tooth specimens using laser ablation (LA-) coupled to ICP-MS. From this comprehensive work, the measurement traceability of manganese in blood, urine, and teeth was characterized; a thorough understanding of the mass spectrometry behind the measurement of manganese was achieved; and the current interlaboratory performance for blood and urine manganese was evaluated.
520 $a Experiments showed that GFAAS is a suitable technique for determining manganese in blood and urine, but for Q-ICP-MS, the use of a reaction/collision gas is necessary to attenuate polyatomic interferences and abundance sensitivity (blood). The use of medium resolution mode in SF-ICP-MS is necessary to avoid these interferences. For manganese in teeth, several methods of calibration for LA-ICP-MS were explored, but accurate quantification still remains a challenge for this technique. Matrix-matched calibrations are required for blood, urine, and teeth in ICP-MS. Using the New York State Department of Health (NYS DOH) Trace Elements Proficiency Testing (PT) Program, interlaboratory performance for blood and urine manganese was summarized as +/-4 mug/L or +/-20% (above 20 mug/L) and +/-1.5 mug/L or +/-20% (above 7.5 mug/L), respectively.
520 $a In conclusion, blood manganese can be used as a biomarker of exposure after careful optimization of analytical techniques. Urine manganese is less useful as concentrations are generally near detection limits. Tooth manganese is an information-rich biomarker, but more work is needed to improve its quantification.
590 $a School code: 0668.
650 4 $a Environmental Health. $3 578282
650 4 $a Chemistry, Analytical. $3 586156
690 $a 0470
690 $a 0486
710 2 $a State University of New York at Albany. $b Environmental Health Sciences. $3 2106377
773 0 $t Dissertation Abstracts International $g 74-10B(E).
790 $a 0668
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3566564