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Investigating Microbial Metabolites ...

Yang, Jane Youngmi.

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Investigating Microbial Metabolites with Novel Mass Spectrometry Tools.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Investigating Microbial Metabolites with Novel Mass Spectrometry Tools./
Author:	Yang, Jane Youngmi.
Description:	165 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-11(E), Section: B.
Contained By:	Dissertation Abstracts International74-11B(E).
Subject:	Chemistry, Biochemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3587196
ISBN:	9781303242212

Investigating Microbial Metabolites with Novel Mass Spectrometry Tools.
Yang, Jane Youngmi.

Investigating Microbial Metabolites with Novel Mass Spectrometry Tools. - 165 p.

Source: Dissertation Abstracts International, Volume: 74-11(E), Section: B.

Thesis (Ph.D.)--University of California, San Diego, 2013.

Microbes are everywhere. One teaspoon of soil contains an estimated 100 million to one billion bacteria. There are 100 million times more bacteria in the ocean than stars in the known universe. And microbes associated with the human body outnumber human cells ten to one. Microbes communicate with their environment through small molecules, also referred to as secondary metabolites. These microbial metabolites modulate cell to cell communication, which affects biological processes such as cellular differentiation within a colony, virulence, and the homeostatic balance between host health and disease.

ISBN: 9781303242212Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

Investigating Microbial Metabolites with Novel Mass Spectrometry Tools.
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020 $a 9781303242212
035 $a (MiAaPQ)AAI3587196
035 $a AAI3587196
040 $a MiAaPQ $c MiAaPQ
100 1 $a Yang, Jane Youngmi. $3 2104676
245 1 0 $a Investigating Microbial Metabolites with Novel Mass Spectrometry Tools.
300 $a 165 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-11(E), Section: B.
500 $a Adviser: Pieter C. Dorrestein.
502 $a Thesis (Ph.D.)--University of California, San Diego, 2013.
520 $a Microbes are everywhere. One teaspoon of soil contains an estimated 100 million to one billion bacteria. There are 100 million times more bacteria in the ocean than stars in the known universe. And microbes associated with the human body outnumber human cells ten to one. Microbes communicate with their environment through small molecules, also referred to as secondary metabolites. These microbial metabolites modulate cell to cell communication, which affects biological processes such as cellular differentiation within a colony, virulence, and the homeostatic balance between host health and disease.
520 $a Understanding these metabolites has implications in many applications, including agriculture and health. Previous studies examine one metabolite at a time, out of the context of the entire colony or community. And although one metabolite may exhibit bioactivity, a microbial community most likely produces multiple molecules simultaneously. In order to begin to understand microbial molecules and their global biological roles in the context of communities, we developed and applied novel mass spectrometry tools to single species colonies, dual species interactions, and phylogenetically distinct microbes.
520 $a The thesis begins with the introduction of matrix assisted laser desorption ionization-time of flight imaging mass spectrometry (MALDI-TOF IMS). This mass spectrometry based tool is used to visualize the two dimensional distribution of metabolites associated with microbial colonies.
520 $a Chapter 2 presents the profiling of microbial metabolites by MALDI-TOF MS and the application of IMS to further understand the regulation and production of secondary metabolites in Bacillus subtilis, and the discussion of the biological implications.
520 $a Chapter 3 introduces mass spectrometry based molecular networking as a strategy to quickly identify the "known unknowns" within complex samples.
520 $a Chapter 4 proposes the application of molecular networking described in the dissertation to investigate honey bee colony collapse disorder.
590 $a School code: 0033.
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Chemistry, Analytical. $3 586156
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0487
690 $a 0486
690 $a 0410
710 2 $a University of California, San Diego. $b Chemistry. $3 1023460
773 0 $t Dissertation Abstracts International $g 74-11B(E).
790 $a 0033
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3587196