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Synthesis and Applications of Bio-De...

Elder, Allison N.

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Synthesis and Applications of Bio-Derived Conjugates.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Synthesis and Applications of Bio-Derived Conjugates./
作者:	Elder, Allison N.
面頁冊數:	158 p.
附註:	Source: Dissertation Abstracts International, Volume: 74-12(E), Section: B.
Contained By:	Dissertation Abstracts International74-12B(E).
標題:	Chemistry, General. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3573481
ISBN:	9781303436703

Synthesis and Applications of Bio-Derived Conjugates.
Elder, Allison N.

Synthesis and Applications of Bio-Derived Conjugates. - 158 p.

Source: Dissertation Abstracts International, Volume: 74-12(E), Section: B.

Thesis (Ph.D.)--Carnegie Mellon University, 2013.

Chemists have always been inspired by nature and have used phenomena found in nature to their advantage. However, nature is slow to evolve and does not always have the answer to a particular solution. Therefore, modification of some of the materials found in nature and conjugation of these materials with synthetic materials can be highly useful and offer synergistic advantages compared to either component on its own. For example, PEGylation of antibodies for therapeutic applications allows for increased circulation times and reduced immunogenicity. Materials such as wood-plastic composites are also useful for outdoor applications like decks because they are more resistant to rot and do not corrode. In both academia and industry, scientists are continually trying to find ways to use and improve compounds found in nature.

ISBN: 9781303436703Subjects--Topical Terms:

1021807
Chemistry, General.

Synthesis and Applications of Bio-Derived Conjugates.
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245 1 0 $a Synthesis and Applications of Bio-Derived Conjugates.
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500 $a Source: Dissertation Abstracts International, Volume: 74-12(E), Section: B.
500 $a Adviser: Newell R. Washburn.
502 $a Thesis (Ph.D.)--Carnegie Mellon University, 2013.
520 $a Chemists have always been inspired by nature and have used phenomena found in nature to their advantage. However, nature is slow to evolve and does not always have the answer to a particular solution. Therefore, modification of some of the materials found in nature and conjugation of these materials with synthetic materials can be highly useful and offer synergistic advantages compared to either component on its own. For example, PEGylation of antibodies for therapeutic applications allows for increased circulation times and reduced immunogenicity. Materials such as wood-plastic composites are also useful for outdoor applications like decks because they are more resistant to rot and do not corrode. In both academia and industry, scientists are continually trying to find ways to use and improve compounds found in nature.
520 $a The focus of this thesis centers on the synthesis, characterization, and applications of conjugates containing both natural and synthetic elements. The scope of topics discussed is very broad and ranges from conjugates with biological applications to others with more materials-type applications. More specifically, Chapter 1 provides an introduction to each of the biologically derived constituents used throughout this thesis and discusses their evolutionary role in nature as well as potential applications. Chapter 2 discusses the synthesis and microbiocidal activities of alkylated bacitracin while Chapter 3 examines the effect of polymer type and length on peptide-polymer binding affinity for TNFalpha. These chapters are a bit more biological in terms of their potential applications.
520 $a The subsequent chapters have a more materials-based focus for their characterization methods and utility. Chapter 4 focuses on the rheological properties of 0-sheet peptide modified hyaluronic acid. Chapter 5 characterizes the rapid loss of adhesion in dopamine methacrylamide copolymers. Chapter 6 is the last bulk chapter of the thesis and focuses on lignin etc. Finally, the last chapter provides the overall conclusions and future directions for each of the five projects.
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