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Mapping Molecular Space with Mass Sp...

Nguyen, Don Duy.

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Mapping Molecular Space with Mass Spectrometry.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Mapping Molecular Space with Mass Spectrometry./
作者:	Nguyen, Don Duy.
面頁冊數:	94 p.
附註:	Source: Masters Abstracts International, Volume: 52-02.
Contained By:	Masters Abstracts International52-02(E).
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1544018
ISBN:	9781303329401

Mapping Molecular Space with Mass Spectrometry.
Nguyen, Don Duy.

Mapping Molecular Space with Mass Spectrometry. - 94 p.

Source: Masters Abstracts International, Volume: 52-02.

Thesis (M.S.)--University of California, San Diego, 2013.

Mass spectrometry has become an invaluable tool in the discovery and characterization of specialized metabolites and biotechnologically relevant molecules. One aspect of characterizing specialized metabolites involves connecting these molecules to their biosynthetic machineries. Here we employ several mass spectrometry methods and introduce the idea of connecting molecular families to their gene cluster families on a large scale that takes advantage of publicly accessible genomes. As proof of principle, we used molecular networking to analyze sixty bacteria, 42 bacilli and 18 pseudomonads, simultaneously and matched eight molecular families to their gene cluster families. To illustrate the effectiveness of this technique, we combined it with imaging mass spectrometry to examine two marine Pseudoalteromonas that both showed inhibition against Bacillus subtilis 3610. The signals showing bioactivity against B. subtilis were shown to be a family of molecules for which the biosynthetic gene cluster was discovered using a publiclyavailable genome sequence from Pseudoalteromonas piscicida JCM 20779T.

ISBN: 9781303329401Subjects--Topical Terms:

586156
Chemistry, Analytical.

Mapping Molecular Space with Mass Spectrometry.
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520 $a Mass spectrometry has become an invaluable tool in the discovery and characterization of specialized metabolites and biotechnologically relevant molecules. One aspect of characterizing specialized metabolites involves connecting these molecules to their biosynthetic machineries. Here we employ several mass spectrometry methods and introduce the idea of connecting molecular families to their gene cluster families on a large scale that takes advantage of publicly accessible genomes. As proof of principle, we used molecular networking to analyze sixty bacteria, 42 bacilli and 18 pseudomonads, simultaneously and matched eight molecular families to their gene cluster families. To illustrate the effectiveness of this technique, we combined it with imaging mass spectrometry to examine two marine Pseudoalteromonas that both showed inhibition against Bacillus subtilis 3610. The signals showing bioactivity against B. subtilis were shown to be a family of molecules for which the biosynthetic gene cluster was discovered using a publiclyavailable genome sequence from Pseudoalteromonas piscicida JCM 20779T.
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