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Epigenetic Modifications of Human Co...

Moseley, Vondina R.

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Epigenetic Modifications of Human Colon Cancer by the Green Tea Polyphenol, Epigallocatechin-3 Gallate, EGCG.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Epigenetic Modifications of Human Colon Cancer by the Green Tea Polyphenol, Epigallocatechin-3 Gallate, EGCG./
Author:	Moseley, Vondina R.
Description:	111 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-12(E), Section: B.
Contained By:	Dissertation Abstracts International74-12B(E).
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3574029
ISBN:	9781303461088

Epigenetic Modifications of Human Colon Cancer by the Green Tea Polyphenol, Epigallocatechin-3 Gallate, EGCG.
Moseley, Vondina R.

Epigenetic Modifications of Human Colon Cancer by the Green Tea Polyphenol, Epigallocatechin-3 Gallate, EGCG. - 111 p.

Source: Dissertation Abstracts International, Volume: 74-12(E), Section: B.

Thesis (Ph.D.)--Medical University of South Carolina, 2013.

Colon cancer is still the second leading cause of cancer deaths in the United States. Epigenetic gene silencing involving DNA Methyltransferases and Historic Deacetylases plays an important role in the progression of colon cancer. We proposed that EGCG inhibits DNMTs and HDACs. Using an in vitro model of colon cancer where key regulatory genes are silenced via methylation, we found that colon cell's sensitivity to methylation plays a role in its response to the green tea polyphenol, EGCG. HDACs and DNMT protein show reduced expression when treated with EGCG in the methylation sensitive HCT 116 human colon cancer cell line but relatively stable expression in the HT-29 cell line. This decreased expression may he partially explained by our finding that DNMT3a and HDAC3 are degraded in the methylation sensitive colon cancer cell line in part by EGCG inhibiting DNMI3a and HDAC3 association with the E3 ubiquitin ligase, UHRF1. These findings provide a rationale for the development of a more targeted therapy for methylation sensitive colon cancers that can include EGCG in combination with other DNMT and HDAC inhibitors.

ISBN: 9781303461088Subjects--Topical Terms:

1017730
Biology, Genetics.

Epigenetic Modifications of Human Colon Cancer by the Green Tea Polyphenol, Epigallocatechin-3 Gallate, EGCG.
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245 1 0 $a Epigenetic Modifications of Human Colon Cancer by the Green Tea Polyphenol, Epigallocatechin-3 Gallate, EGCG.
300 $a 111 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-12(E), Section: B.
500 $a Adviser: Michael J. Wargovich.
502 $a Thesis (Ph.D.)--Medical University of South Carolina, 2013.
520 $a Colon cancer is still the second leading cause of cancer deaths in the United States. Epigenetic gene silencing involving DNA Methyltransferases and Historic Deacetylases plays an important role in the progression of colon cancer. We proposed that EGCG inhibits DNMTs and HDACs. Using an in vitro model of colon cancer where key regulatory genes are silenced via methylation, we found that colon cell's sensitivity to methylation plays a role in its response to the green tea polyphenol, EGCG. HDACs and DNMT protein show reduced expression when treated with EGCG in the methylation sensitive HCT 116 human colon cancer cell line but relatively stable expression in the HT-29 cell line. This decreased expression may he partially explained by our finding that DNMT3a and HDAC3 are degraded in the methylation sensitive colon cancer cell line in part by EGCG inhibiting DNMI3a and HDAC3 association with the E3 ubiquitin ligase, UHRF1. These findings provide a rationale for the development of a more targeted therapy for methylation sensitive colon cancers that can include EGCG in combination with other DNMT and HDAC inhibitors.
590 $a School code: 0122.
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650 4 $a Health Sciences, Oncology. $3 1018566
650 4 $a Chemistry, Biochemistry. $3 1017722
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710 2 $a Medical University of South Carolina. $b Molecular Cell Biology and Pathobiology. $3 2103698
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3574029