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Saccharomyces cerevisiae produces th...

Chikhalya, Aniska Yogesh.

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Saccharomyces cerevisiae produces the immunomodulatory prostaglandin E2.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Saccharomyces cerevisiae produces the immunomodulatory prostaglandin E2./
Author:	Chikhalya, Aniska Yogesh.
Description:	49 p.
Notes:	Source: Masters Abstracts International, Volume: 51-05.
Contained By:	Masters Abstracts International51-05(E).
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1522620
ISBN:	9781303020322

Saccharomyces cerevisiae produces the immunomodulatory prostaglandin E2.
Chikhalya, Aniska Yogesh.

Saccharomyces cerevisiae produces the immunomodulatory prostaglandin E2. - 49 p.

Source: Masters Abstracts International, Volume: 51-05.

Thesis (M.S.)--California State University, Long Beach, 2013.

Prostaglandin E2 (PGE2) is a bioactive lipid signaling molecule implicated in a range of inflammatory diseases and cancers. In humans, PGE2 is biosynthesized by sequential oxidation of arachidonic acid (AA) by cyclooxygenases (COX) and prostaglandin E2 synthase (PTGES). Studies have shown at least two pathogenic fungi of humans to produce PGE 2, which is thought to potentiate their invasive properties. Our studies show that Saccharomyces cerevisiae, a saprophytic fungus, also produces at least 500 pg/ml of PGE2 when cultured in the presence of AA. PGE2 produced by S. cerevisiae is of concern because this fungus is utilized to manufacture a wide range of products including alcoholic beverages, and recombinant proteins for vaccines and therapeutics. The sequenced genomes of fungi, including S. cerevisiae lack genes homologous to mammalian COX and PTGES, which suggests a novel biochemical pathway for PGE2 biosynthesis by fungi. Treatment with 1 mM cyclooxygenase (COX) and lipoxygenase (LOX) inhibitors reduced production of PGE2, suggesting that enzymes with active sites that are similar to both COX and LOX may be responsible for PGE2 production by S. cerevisiae. Detection of PGE2 in beer (150-500 pg/ml) and sake suggests that S. cerevisiae is capable of utilizing a wide range of fatty acids to produce PGE2. The discovery that S. cerevisiae a saprophytic and model biological fungus produces PGE2 has potentially broad implications for understanding the mechanisms of eicosanoid production in both pathogenic and non-pathogenic fungi, and has relevance to disease.

ISBN: 9781303020322Subjects--Topical Terms:

1017734
Biology, Microbiology.

Saccharomyces cerevisiae produces the immunomodulatory prostaglandin E2.
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100 1 $a Chikhalya, Aniska Yogesh. $3 2103583
245 1 0 $a Saccharomyces cerevisiae produces the immunomodulatory prostaglandin E2.
300 $a 49 p.
500 $a Source: Masters Abstracts International, Volume: 51-05.
500 $a Adviser: Eric Haas-Stapleton.
502 $a Thesis (M.S.)--California State University, Long Beach, 2013.
520 $a Prostaglandin E2 (PGE2) is a bioactive lipid signaling molecule implicated in a range of inflammatory diseases and cancers. In humans, PGE2 is biosynthesized by sequential oxidation of arachidonic acid (AA) by cyclooxygenases (COX) and prostaglandin E2 synthase (PTGES). Studies have shown at least two pathogenic fungi of humans to produce PGE 2, which is thought to potentiate their invasive properties. Our studies show that Saccharomyces cerevisiae, a saprophytic fungus, also produces at least 500 pg/ml of PGE2 when cultured in the presence of AA. PGE2 produced by S. cerevisiae is of concern because this fungus is utilized to manufacture a wide range of products including alcoholic beverages, and recombinant proteins for vaccines and therapeutics. The sequenced genomes of fungi, including S. cerevisiae lack genes homologous to mammalian COX and PTGES, which suggests a novel biochemical pathway for PGE2 biosynthesis by fungi. Treatment with 1 mM cyclooxygenase (COX) and lipoxygenase (LOX) inhibitors reduced production of PGE2, suggesting that enzymes with active sites that are similar to both COX and LOX may be responsible for PGE2 production by S. cerevisiae. Detection of PGE2 in beer (150-500 pg/ml) and sake suggests that S. cerevisiae is capable of utilizing a wide range of fatty acids to produce PGE2. The discovery that S. cerevisiae a saprophytic and model biological fungus produces PGE2 has potentially broad implications for understanding the mechanisms of eicosanoid production in both pathogenic and non-pathogenic fungi, and has relevance to disease.
590 $a School code: 6080.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Chemistry, Biochemistry. $3 1017722
690 $a 0410
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690 $a 0487
710 2 $a California State University, Long Beach. $b Biological Sciences. $3 2103584
773 0 $t Masters Abstracts International $g 51-05(E).
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