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Growth Signaling in Aging and Disease.

Johnson, Simon C.

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Growth Signaling in Aging and Disease.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Growth Signaling in Aging and Disease./
Author:	Johnson, Simon C.
Description:	96 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.
Contained By:	Dissertation Abstracts International75-02B(E).
Subject:	Health Sciences, Aging. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3599734
ISBN:	9781303494413

Growth Signaling in Aging and Disease.
Johnson, Simon C.

Growth Signaling in Aging and Disease. - 96 p.

Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.

Thesis (Ph.D.)--University of Washington, 2013.

Nutrient sensing and growth signaling pathways are key regulators of healthspan and longevity. Caloric restriction, the most widely studied and well documented intervention in aging, functions largely through effects on nutrient sensing and growth signaling pathways. Genetic approaches to studying aging have further emphasized the central role that growth signaling plays in regulating longevity by identifying key components of growth signaling pathways as critical modifiers of the aging process. Among these genetic factors are the insulin/insulin-like growth factor signaling, AMP kinase, and the mechanistic target of rapamycin (mTOR) complexes. mTOR forms two distinct complexes, mTORC1 and mTORC2, which together act as central coordinators of a variety of intra- and extra-cellular nutrient and growth signals. mTOR integrates extracellular signaling through insulin, IGF, and Akt, intracellular energy status sensing by AMP kinase, intracellular amino acid levels through sensing at the lysosome, and cellular translational capacity through association with the ribosome, As a central regulator of a variety of critical energy sensing pathways mTOR has been demonstrated to significantly contribute to aging and disease. Pathways downstream of mTOR include translation, autophagy, metabolism, and inflammation. The studies presented here examine the relationship between genotype and response to caloric restriction, examining the therapeutic role of mTOR inhibition in a mouse model of a human mitochondrial disease, and investigating the role of a major molecular process regulated by mTOR, autophagy, in the development of cardiac hypertrophy. These studies are diverse but linked by a central focus on the role of growth signaling pathways in aging and human disease and the work presented here provides important and novel insights into disease and aging.

ISBN: 9781303494413Subjects--Topical Terms:

1669845
Health Sciences, Aging.

Growth Signaling in Aging and Disease.
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020 $a 9781303494413
035 $a (MiAaPQ)AAI3599734
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100 1 $a Johnson, Simon C. $3 2102707
245 1 0 $a Growth Signaling in Aging and Disease.
300 $a 96 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.
500 $a Advisers: Peter Rabinovitch; Matt Kaeberlein.
502 $a Thesis (Ph.D.)--University of Washington, 2013.
520 $a Nutrient sensing and growth signaling pathways are key regulators of healthspan and longevity. Caloric restriction, the most widely studied and well documented intervention in aging, functions largely through effects on nutrient sensing and growth signaling pathways. Genetic approaches to studying aging have further emphasized the central role that growth signaling plays in regulating longevity by identifying key components of growth signaling pathways as critical modifiers of the aging process. Among these genetic factors are the insulin/insulin-like growth factor signaling, AMP kinase, and the mechanistic target of rapamycin (mTOR) complexes. mTOR forms two distinct complexes, mTORC1 and mTORC2, which together act as central coordinators of a variety of intra- and extra-cellular nutrient and growth signals. mTOR integrates extracellular signaling through insulin, IGF, and Akt, intracellular energy status sensing by AMP kinase, intracellular amino acid levels through sensing at the lysosome, and cellular translational capacity through association with the ribosome, As a central regulator of a variety of critical energy sensing pathways mTOR has been demonstrated to significantly contribute to aging and disease. Pathways downstream of mTOR include translation, autophagy, metabolism, and inflammation. The studies presented here examine the relationship between genotype and response to caloric restriction, examining the therapeutic role of mTOR inhibition in a mouse model of a human mitochondrial disease, and investigating the role of a major molecular process regulated by mTOR, autophagy, in the development of cardiac hypertrophy. These studies are diverse but linked by a central focus on the role of growth signaling pathways in aging and human disease and the work presented here provides important and novel insights into disease and aging.
590 $a School code: 0250.
650 4 $a Health Sciences, Aging. $3 1669845
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Health Sciences, Pathology. $3 1017854
690 $a 0493
690 $a 0307
690 $a 0571
710 2 $a University of Washington. $b Pathology. $3 2101072
773 0 $t Dissertation Abstracts International $g 75-02B(E).
790 $a 0250
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3599734