東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Type 2 diabetes, risk of dementia an...

Mayeda, Elizabeth Rose.

FindBook

Google Book

Amazon

博客來

Type 2 diabetes, risk of dementia and cognitive decline, and the competing risk of mortality among middle-aged and older adults.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Type 2 diabetes, risk of dementia and cognitive decline, and the competing risk of mortality among middle-aged and older adults./
作者:	Mayeda, Elizabeth Rose.
面頁冊數:	73 p.
附註:	Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.
Contained By:	Dissertation Abstracts International75-02B(E).
標題:	Health Sciences, Epidemiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3599397
ISBN:	9781303486388

Type 2 diabetes, risk of dementia and cognitive decline, and the competing risk of mortality among middle-aged and older adults.
Mayeda, Elizabeth Rose.

Type 2 diabetes, risk of dementia and cognitive decline, and the competing risk of mortality among middle-aged and older adults. - 73 p.

Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.

Thesis (Ph.D.)--University of California, San Francisco, 2013.

Type 2 diabetes is highly prevalent and has been linked with an increased risk of dementia and premature mortality. Earlier death among people with diabetes may impact the association between diabetes and dementia. This is particularly important for populations with a high burden of diabetes, including Mexican Americans and African Americans. The objective of this dissertation was to evaluate the association of diabetes with incidence of dementia and cognitive impairment without dementia (CIND) and cognitive decline in late-life among Mexican Americans and in mid-life among African Americans and whites while accounting for the competing risk of mortality. The study populations included: 1) a cohort of dementia-free older Mexican Americans (n=1617) aged 60-98 from the Sacramento Area Latino Study on Aging (SALSA) followed for 10 years beginning in 1998 and 2) a cohort of middle-aged African Americans and whites (n=1886) aged 48-70 from the Atherosclerosis Risk in Communities (ARIC) Study followed for 14 years beginning in 1990. The association between diabetes and incidence of dementia/CIND was examined with competing risk regression models in the SALSA cohort and the association between diabetes and cognitive decline was examined with joint longitudinal-survival models in the SALSA and ARIC cohorts. In the SALSA cohort, Mexican Americans with treated and untreated diabetes had an increased risk of dementia/CIND compared to those without diabetes (HR=2.05, 95% CI: 1.41-2.97 and HR=1.55, 95% CI: 0.93-2.58) after accounting for the competing risk of death. Additionally, Mexican Americans with diabetes experienced modestly accelerated cognitive decline compared to those without diabetes. In the ARIC cohort, earlier onset of diabetes was associated with greater cognitive decline in mid-life among African Americans. No association between diabetes and cognitive decline was observed among whites. These findings provide evidence that the association between diabetes and dementia/CIND among Mexican Americans remains strong after accounting for the competing risk of mortality. The association between diabetes and cognitive decline is less evident. Future research is needed to identify how diabetes treatments influence cognitive decline among people with diabetes.

ISBN: 9781303486388Subjects--Topical Terms:

1019544
Health Sciences, Epidemiology.

Type 2 diabetes, risk of dementia and cognitive decline, and the competing risk of mortality among middle-aged and older adults.
LDR:03230nam a2200277 4500 001 1965947
005 20141124082815.5
008 150210s2013 ||||||||||||||||| ||eng d
020 $a 9781303486388
035 $a (MiAaPQ)AAI3599397
035 $a AAI3599397
040 $a MiAaPQ $c MiAaPQ
100 1 $a Mayeda, Elizabeth Rose. $3 2102705
245 1 0 $a Type 2 diabetes, risk of dementia and cognitive decline, and the competing risk of mortality among middle-aged and older adults.
300 $a 73 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-02(E), Section: B.
500 $a Adviser: Mary N. Haan.
502 $a Thesis (Ph.D.)--University of California, San Francisco, 2013.
520 $a Type 2 diabetes is highly prevalent and has been linked with an increased risk of dementia and premature mortality. Earlier death among people with diabetes may impact the association between diabetes and dementia. This is particularly important for populations with a high burden of diabetes, including Mexican Americans and African Americans. The objective of this dissertation was to evaluate the association of diabetes with incidence of dementia and cognitive impairment without dementia (CIND) and cognitive decline in late-life among Mexican Americans and in mid-life among African Americans and whites while accounting for the competing risk of mortality. The study populations included: 1) a cohort of dementia-free older Mexican Americans (n=1617) aged 60-98 from the Sacramento Area Latino Study on Aging (SALSA) followed for 10 years beginning in 1998 and 2) a cohort of middle-aged African Americans and whites (n=1886) aged 48-70 from the Atherosclerosis Risk in Communities (ARIC) Study followed for 14 years beginning in 1990. The association between diabetes and incidence of dementia/CIND was examined with competing risk regression models in the SALSA cohort and the association between diabetes and cognitive decline was examined with joint longitudinal-survival models in the SALSA and ARIC cohorts. In the SALSA cohort, Mexican Americans with treated and untreated diabetes had an increased risk of dementia/CIND compared to those without diabetes (HR=2.05, 95% CI: 1.41-2.97 and HR=1.55, 95% CI: 0.93-2.58) after accounting for the competing risk of death. Additionally, Mexican Americans with diabetes experienced modestly accelerated cognitive decline compared to those without diabetes. In the ARIC cohort, earlier onset of diabetes was associated with greater cognitive decline in mid-life among African Americans. No association between diabetes and cognitive decline was observed among whites. These findings provide evidence that the association between diabetes and dementia/CIND among Mexican Americans remains strong after accounting for the competing risk of mortality. The association between diabetes and cognitive decline is less evident. Future research is needed to identify how diabetes treatments influence cognitive decline among people with diabetes.
590 $a School code: 0034.
650 4 $a Health Sciences, Epidemiology. $3 1019544
650 4 $a Health Sciences, Aging. $3 1669845
690 $a 0766
690 $a 0493
710 2 $a University of California, San Francisco. $b Epidemiology and Translational Science. $3 2102706
773 0 $t Dissertation Abstracts International $g 75-02B(E).
790 $a 0034
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3599397