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The effect of maternal exercise duri...

Bahls, Martin.

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The effect of maternal exercise during pregnancy on offspring vascular function in swine.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The effect of maternal exercise during pregnancy on offspring vascular function in swine./
Author:	Bahls, Martin.
Description:	134 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-12(E), Section: B.
Contained By:	Dissertation Abstracts International74-12B(E).
Subject:	Health Sciences, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3591150
ISBN:	9781303316968

The effect of maternal exercise during pregnancy on offspring vascular function in swine.
Bahls, Martin.

The effect of maternal exercise during pregnancy on offspring vascular function in swine. - 134 p.

Source: Dissertation Abstracts International, Volume: 74-12(E), Section: B.

Thesis (Ph.D.)--Purdue University, 2013.

Maternal behavior influences the intrauterine environment and programs lifelong atherosclerotic disease susceptibility in offspring. An increased atherosclerotic disease risk has previously been reported for adult progeny exposed to an adverse in utero environment. Very few studies have investigated whether positive maternal health behaviors during pregnancy reduce atherosclerotic disease risk in offspring. The purpose of this investigation was to test the hypothesis that maternal exercise during pregnancy improves endothelial function in offspring. Six months old swine were randomly assigned to an exercise (n = 7) or sedentary (n = 8) group throughout pregnancy. Exercise consisted of treadmill running for 20-45 min, five times per week, for all but the last week of gestation. Vascular reactivity was measured using dose-dependent endothelium-dependent (bradykinin (BK); 10-11 -10-6 M) and -independent (sodium nitroprusside (SNP); 10-10 - 10-4 M) vasorelaxation in femoral arteries from offspring at 3, 5, and 9 months of age using in vitro wire-myography. L-Name (300 muM) was used to block nitric oxide (NO) signaling in BK-induced relaxation. Quantitative PCR and Western blotting were used to assess transcript and protein abundance, respectively, of eNOS, GUCY1A2, GUCY1A3, GUCY1B3, PRKG1, MYPT1, PPP1R14A, and SERCA2. Exercise had no effect on BK relaxation with and without L-Name. A main effect on SNP relaxation (P < 0.01) was observed. Furthermore, a significant age x treatment interaction for SNP (P < 0.05) manifested by a reduced SNP relaxation response in offspring of exercised trained compared to sedentary swine at 3 (P < 0.01), 5 (P < 0.05), and 9 months (P < 0.05) of age was identified. A significant main effect was observed for PPP14R1 (P < 0.05) and differential regulation of its protein product CPI-17. Contrary to our hypothesis, exercise during pregnancy does not alter BK-induced endothelial function via NO signaling. However, programming of NO-induced cGMP-dependent vascular smooth relaxation may contribute to a reduced vasorelaxation response in offspring from exercise trained compared to sedentary swine.

ISBN: 9781303316968Subjects--Topical Terms:

1017817
Health Sciences, General.

The effect of maternal exercise during pregnancy on offspring vascular function in swine.
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100 1 $a Bahls, Martin. $3 2102672
245 1 4 $a The effect of maternal exercise during pregnancy on offspring vascular function in swine.
300 $a 134 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-12(E), Section: B.
500 $a Advisers: Sean C. Newcomer; Laura J. Claxton; Ryan C. Cabot; Shawn S. Donkin.
502 $a Thesis (Ph.D.)--Purdue University, 2013.
520 $a Maternal behavior influences the intrauterine environment and programs lifelong atherosclerotic disease susceptibility in offspring. An increased atherosclerotic disease risk has previously been reported for adult progeny exposed to an adverse in utero environment. Very few studies have investigated whether positive maternal health behaviors during pregnancy reduce atherosclerotic disease risk in offspring. The purpose of this investigation was to test the hypothesis that maternal exercise during pregnancy improves endothelial function in offspring. Six months old swine were randomly assigned to an exercise (n = 7) or sedentary (n = 8) group throughout pregnancy. Exercise consisted of treadmill running for 20-45 min, five times per week, for all but the last week of gestation. Vascular reactivity was measured using dose-dependent endothelium-dependent (bradykinin (BK); 10-11 -10-6 M) and -independent (sodium nitroprusside (SNP); 10-10 - 10-4 M) vasorelaxation in femoral arteries from offspring at 3, 5, and 9 months of age using in vitro wire-myography. L-Name (300 muM) was used to block nitric oxide (NO) signaling in BK-induced relaxation. Quantitative PCR and Western blotting were used to assess transcript and protein abundance, respectively, of eNOS, GUCY1A2, GUCY1A3, GUCY1B3, PRKG1, MYPT1, PPP1R14A, and SERCA2. Exercise had no effect on BK relaxation with and without L-Name. A main effect on SNP relaxation (P < 0.01) was observed. Furthermore, a significant age x treatment interaction for SNP (P < 0.05) manifested by a reduced SNP relaxation response in offspring of exercised trained compared to sedentary swine at 3 (P < 0.01), 5 (P < 0.05), and 9 months (P < 0.05) of age was identified. A significant main effect was observed for PPP14R1 (P < 0.05) and differential regulation of its protein product CPI-17. Contrary to our hypothesis, exercise during pregnancy does not alter BK-induced endothelial function via NO signaling. However, programming of NO-induced cGMP-dependent vascular smooth relaxation may contribute to a reduced vasorelaxation response in offspring from exercise trained compared to sedentary swine.
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650 4 $a Biology, Evolution and Development. $3 1675612
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710 2 $a Purdue University. $b Health and Kinesiology. $3 1278622
773 0 $t Dissertation Abstracts International $g 74-12B(E).
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