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Cardiovascular Risk Factors and Inci...

Mozaffar, Farah Haque.

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Cardiovascular Risk Factors and Incidence of Dementia in the Oldest Old.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Cardiovascular Risk Factors and Incidence of Dementia in the Oldest Old./
Author:	Mozaffar, Farah Haque.
Description:	88 p.
Notes:	Source: Masters Abstracts International, Volume: 52-02.
Contained By:	Masters Abstracts International52-02(E).
Subject:	Health Sciences, Aging. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1546031
ISBN:	9781303437809

Cardiovascular Risk Factors and Incidence of Dementia in the Oldest Old.
Mozaffar, Farah Haque.

Cardiovascular Risk Factors and Incidence of Dementia in the Oldest Old. - 88 p.

Source: Masters Abstracts International, Volume: 52-02.

Thesis (M.S.)--University of California, Irvine, 2013.

Objective: To analyze the relationship of cardiovascular risk factors and incidence of all cause dementia in the oldest-old.

ISBN: 9781303437809Subjects--Topical Terms:

1669845
Health Sciences, Aging.

Cardiovascular Risk Factors and Incidence of Dementia in the Oldest Old.
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020 $a 9781303437809
035 $a (MiAaPQ)AAI1546031
035 $a AAI1546031
040 $a MiAaPQ $c MiAaPQ
100 1 $a Mozaffar, Farah Haque. $3 2102539
245 1 0 $a Cardiovascular Risk Factors and Incidence of Dementia in the Oldest Old.
300 $a 88 p.
500 $a Source: Masters Abstracts International, Volume: 52-02.
500 $a Adviser: Sheldon Greenfield.
502 $a Thesis (M.S.)--University of California, Irvine, 2013.
520 $a Objective: To analyze the relationship of cardiovascular risk factors and incidence of all cause dementia in the oldest-old.
520 $a Background: Numerous cardiovascular risk factors have been studied in relation to dementia in the elderly population but not in the oldest-old, the population above the age of 90 years that happens to be growing faster not only in US but all over the world. As the people are living longer, the health care burden has increased, resulting in more institutionalizations and increasing disability. Furthermore there is an increased prevalence and incidence of dementia in this age group. This study aims to study dementia incidence in relation to cardiovascular risk factors such as high blood pressure, high cholesterol, diabetes, cerebrovascular disease (stroke, transient ischemic attack (TIA)) and cardiac diseases (congestive heart failure, myocardial infarction, coronary artery disease, arrhythmias, and heart valve disease).
520 $a Methods: The data is obtained from the 90+ Study, which is a longitudinal cohort study of 90 years and older population resident of Laguna Woods Village. In 2003, the "survivors" of Leisure World Cohort Study were invited to join The 90+ Study. The study included in-person evaluation with update in medical history, medications and physical activities. Trained neurological examinations completed neurological exams and neurological psychometric testing. DSM-IV criteria were used to diagnose dementia. Only non-demented subjects at baseline were included in the analysis. This study analyzed self-reported medical history of high blood pressure, high cholesterol, stroke, TIA, congestive heart failure, arrhythmias, coronary artery disease, myocardial infarction and heart valve disease. Blood was drawn for various tests including APOE genotyping. First diagnosis of all-cause dementia was analyzed as the event of interest, then diagnosis of different types of dementia were analyzed as the events of interest. Survival analysis, cox regression method was used adjusted for age, gender and education.
520 $a Results: Total of 599 subjects were analyzed, 60% female, mostly had some college or higher education, about 40% lived independently. 53% had history of high blood pressure, 34% had history of high cholesterol and between 10-20% had cardiac diseases. Our results showed that high blood pressure was associated with decreased risk of developing all cause dementia. High cholesterol showed the same trend but stroke and CHF were associated with increased risk of developing all cause dementia. For Alzheimer's type dementia, high blood pressure was a protective factor, while high cholesterol showed protective association for vascular type dementia. Stroke, TIA and heart valve disease increased the risk of vascular type dementia. ApoE interaction with these cardiovascular risk factor showed increase risk with history of TIA, myocardial infarction and coronary artery disease for all cause dementia as compared when analyzed alone.
520 $a Conclusion: Different cardiovascular risk factors behave differently when evaluated for risks of developing all-cause, Alzheimer's type or vascular dementia. Importantly history of high blood pressure and high cholesterol showed a protective effect towards development of dementia while congestive heart failure specifically is associated with an increased risk of developing all cause dementia in the Oldest Old.
590 $a School code: 0030.
650 4 $a Health Sciences, Aging. $3 1669845
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
690 $a 0493
690 $a 0564
710 2 $a University of California, Irvine. $b Biomedical and Translational Science. $3 2102540
773 0 $t Masters Abstracts International $g 52-02(E).
790 $a 0030
791 $a M.S.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1546031