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Expression of alpha 7 integrin media...

Ingram, Norianne Theresa.

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Expression of alpha 7 integrin mediates the effects of laminin on Olfactory Ensheathing Cells.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Expression of alpha 7 integrin mediates the effects of laminin on Olfactory Ensheathing Cells./
Author:	Ingram, Norianne Theresa.
Description:	47 p.
Notes:	Source: Masters Abstracts International, Volume: 52-02.
Contained By:	Masters Abstracts International52-02(E).
Subject:	Biology, Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1545574
ISBN:	9781303406683

Expression of alpha 7 integrin mediates the effects of laminin on Olfactory Ensheathing Cells.
Ingram, Norianne Theresa.

Expression of alpha 7 integrin mediates the effects of laminin on Olfactory Ensheathing Cells. - 47 p.

Source: Masters Abstracts International, Volume: 52-02.

Thesis (M.S.)--University of California, Los Angeles, 2013.

Olfactory ensheathing cells (OECs) are unique glia found only in the olfactory system. OECs support neuronal turnover and axon outgrowth in adults and represent a promising cell-transplantation candidate for spinal cord injury repair. Current mechanistic hypotheses are based on the ability of OECs to stimulate neuronal outgrowth via both secreted and cell-contact mediated effects. Laminin is reported to stimulate the growth promoting abilities of OECs, and this study askes if OECs react to laminin using integrin receptors to enhance their function. We focus on the alpha7 integrin that is expressed by Schwann cells and implicated in peripheral nerve regeneration. Here we ask if adult OECs express alpha7 integrin and if the presence of alpha7 integrin mediates the OEC response on laminin by increasing their motility. We found that alpha7 integrin colocalized with established OEC markers, SOX10, S100, and Aquaporin1. When adult OEC motility on laminin was tested, twice as many wildtype OECs migrated on laminin compared to alpha7 mutant OECs. These results show that alpha7 integrin mediates the OEC substrate preference for laminin, the first demonstration of a functional role for alpha7 integrin in OECs.

ISBN: 9781303406683Subjects--Topical Terms:

1017816
Biology, Physiology.

Expression of alpha 7 integrin mediates the effects of laminin on Olfactory Ensheathing Cells.
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020 $a 9781303406683
035 $a (MiAaPQ)AAI1545574
035 $a AAI1545574
040 $a MiAaPQ $c MiAaPQ
100 1 $a Ingram, Norianne Theresa. $3 2102359
245 1 0 $a Expression of alpha 7 integrin mediates the effects of laminin on Olfactory Ensheathing Cells.
300 $a 47 p.
500 $a Source: Masters Abstracts International, Volume: 52-02.
500 $a Adviser: Patricia E. Phelps.
502 $a Thesis (M.S.)--University of California, Los Angeles, 2013.
520 $a Olfactory ensheathing cells (OECs) are unique glia found only in the olfactory system. OECs support neuronal turnover and axon outgrowth in adults and represent a promising cell-transplantation candidate for spinal cord injury repair. Current mechanistic hypotheses are based on the ability of OECs to stimulate neuronal outgrowth via both secreted and cell-contact mediated effects. Laminin is reported to stimulate the growth promoting abilities of OECs, and this study askes if OECs react to laminin using integrin receptors to enhance their function. We focus on the alpha7 integrin that is expressed by Schwann cells and implicated in peripheral nerve regeneration. Here we ask if adult OECs express alpha7 integrin and if the presence of alpha7 integrin mediates the OEC response on laminin by increasing their motility. We found that alpha7 integrin colocalized with established OEC markers, SOX10, S100, and Aquaporin1. When adult OEC motility on laminin was tested, twice as many wildtype OECs migrated on laminin compared to alpha7 mutant OECs. These results show that alpha7 integrin mediates the OEC substrate preference for laminin, the first demonstration of a functional role for alpha7 integrin in OECs.
590 $a School code: 0031.
650 4 $a Biology, Physiology. $3 1017816
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Cell. $3 1017686
690 $a 0719
690 $a 0317
690 $a 0379
710 2 $a University of California, Los Angeles. $b Physiological Science. $3 2102360
773 0 $t Masters Abstracts International $g 52-02(E).
790 $a 0031
791 $a M.S.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1545574