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Development of a protein antigen bas...

Schoofs, Amy Danielle.

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Development of a protein antigen based pneumococcal vaccine utilizing a polyanhydride nanoparticle delivery platform.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Development of a protein antigen based pneumococcal vaccine utilizing a polyanhydride nanoparticle delivery platform./
Author:	Schoofs, Amy Danielle.
Description:	72 p.
Notes:	Source: Masters Abstracts International, Volume: 52-01.
Contained By:	Masters Abstracts International52-01(E).
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1540121
ISBN:	9781303169274

Development of a protein antigen based pneumococcal vaccine utilizing a polyanhydride nanoparticle delivery platform.
Schoofs, Amy Danielle.

Development of a protein antigen based pneumococcal vaccine utilizing a polyanhydride nanoparticle delivery platform. - 72 p.

Source: Masters Abstracts International, Volume: 52-01.

Thesis (M.S.)--Iowa State University, 2013.

Streptococcus pneumoniae is the primary cause of bacterial pneumonia and contributes to millions of deaths worldwide annually. The current capsule polysaccharide based vaccines do provide some protection, but the 7 to 23 valent formulations cannot protect against the over 90 serotypes currently known. Pneumococcal surface protein A (PspA) is a promising candidate for a protein-based vaccine against S. pneumoniae, showing protection in immunized mice and providing the advantage of universal protection from all serotypes of the bacterium. This project shows the results of immunizing CBA/N mice intranasally and subcutaneously with PspA encapsulated into a novel polyanhydride nanoparticle delivery platform in attempt to create a protective protein-based pneumococcal vaccine against bacterial challenge.

ISBN: 9781303169274Subjects--Topical Terms:

1017734
Biology, Microbiology.

Development of a protein antigen based pneumococcal vaccine utilizing a polyanhydride nanoparticle delivery platform.
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100 1 $a Schoofs, Amy Danielle. $3 2102336
245 1 0 $a Development of a protein antigen based pneumococcal vaccine utilizing a polyanhydride nanoparticle delivery platform.
300 $a 72 p.
500 $a Source: Masters Abstracts International, Volume: 52-01.
500 $a Adviser: Michael J. Wannemuehler.
502 $a Thesis (M.S.)--Iowa State University, 2013.
520 $a Streptococcus pneumoniae is the primary cause of bacterial pneumonia and contributes to millions of deaths worldwide annually. The current capsule polysaccharide based vaccines do provide some protection, but the 7 to 23 valent formulations cannot protect against the over 90 serotypes currently known. Pneumococcal surface protein A (PspA) is a promising candidate for a protein-based vaccine against S. pneumoniae, showing protection in immunized mice and providing the advantage of universal protection from all serotypes of the bacterium. This project shows the results of immunizing CBA/N mice intranasally and subcutaneously with PspA encapsulated into a novel polyanhydride nanoparticle delivery platform in attempt to create a protective protein-based pneumococcal vaccine against bacterial challenge.
590 $a School code: 0097.
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0410
710 2 $a Iowa State University. $b Veterinary Microbiology and Preventative Medicine. $3 1017891
773 0 $t Masters Abstracts International $g 52-01(E).
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792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1540121