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Nanomachines on Porous Silica Nanopa...

Tarn, Derrick.

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Nanomachines on Porous Silica Nanoparticles for Cargo Delivery.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Nanomachines on Porous Silica Nanoparticles for Cargo Delivery./
Author:	Tarn, Derrick.
Description:	200 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.
Contained By:	Dissertation Abstracts International74-10B(E).
Subject:	Chemistry, Inorganic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3564093
ISBN:	9781303126598

Nanomachines on Porous Silica Nanoparticles for Cargo Delivery.
Tarn, Derrick.

Nanomachines on Porous Silica Nanoparticles for Cargo Delivery. - 200 p.

Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2013.

The field of nanomachines based on mesoporous and microporous silica nanoparticles is a relatively new one, but has quickly gained widespread popularity due to their large potential applications. These porous nanomaterials can both carry and release a therapeutic drug molecule at a targeted location. In order to regulate the movement of cargo, nanomachines are designed and assembled onto the silica nanoparticle, ultimately creating a delivery system on the nanoscale that is capable of a stimulus-responsive delivery of its cargo.

ISBN: 9781303126598Subjects--Topical Terms:

517253
Chemistry, Inorganic.

Nanomachines on Porous Silica Nanoparticles for Cargo Delivery.
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020 $a 9781303126598
035 $a (MiAaPQ)AAI3564093
035 $a AAI3564093
040 $a MiAaPQ $c MiAaPQ
100 1 $a Tarn, Derrick. $3 2102228
245 1 0 $a Nanomachines on Porous Silica Nanoparticles for Cargo Delivery.
300 $a 200 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.
500 $a Adviser: Jeffrey I. Zink.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2013.
520 $a The field of nanomachines based on mesoporous and microporous silica nanoparticles is a relatively new one, but has quickly gained widespread popularity due to their large potential applications. These porous nanomaterials can both carry and release a therapeutic drug molecule at a targeted location. In order to regulate the movement of cargo, nanomachines are designed and assembled onto the silica nanoparticle, ultimately creating a delivery system on the nanoscale that is capable of a stimulus-responsive delivery of its cargo.
520 $a This dissertation focuses on the design, synthesis and assembly of nanomachines on both meso- and microporous silica nanoparticles to achieve the goal of cargo delivery. The six chapters of this dissertation are presented as follows: 1) the design, synthesis and modification of silica nanoparticles for their use in biology, 2) a light activated, reversible nanovalve assembled on mesoporous silica nanoparticles to achieve a size-selective cargo delivery, 3) biological applications and the delivery of anti-cancer drugs using a pseudorotaxane-based light activated nanovalve, 4) a nanogate machine that is capable of the storage and delivery of both small metal ions and useful organic cargo molecules, 5) biological applications of the nanogate machine in order to deliver calcium ions to cancerous cells to induce cell apoptosis, and 6) thin wax coated microporous silica nanoparticles that are capable of delivering small ions including oxidizers.
590 $a School code: 0031.
650 4 $a Chemistry, Inorganic. $3 517253
650 4 $a Nanotechnology. $3 526235
690 $a 0488
690 $a 0652
710 2 $a University of California, Los Angeles. $b Chemistry 0153. $3 2096181
773 0 $t Dissertation Abstracts International $g 74-10B(E).
790 $a 0031
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3564093