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Investigations into the metabolic re...

Falkard, Brie.

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Investigations into the metabolic requirements for lipoic acid and lipid species during the life cycle of the malarial parasite Plasmodium berghei.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Investigations into the metabolic requirements for lipoic acid and lipid species during the life cycle of the malarial parasite Plasmodium berghei./
Author:	Falkard, Brie.
Description:	176 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-04(E), Section: B.
Contained By:	Dissertation Abstracts International74-04B(E).
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3546949
ISBN:	9781267812353

Investigations into the metabolic requirements for lipoic acid and lipid species during the life cycle of the malarial parasite Plasmodium berghei.
Falkard, Brie.

Investigations into the metabolic requirements for lipoic acid and lipid species during the life cycle of the malarial parasite Plasmodium berghei. - 176 p.

Source: Dissertation Abstracts International, Volume: 74-04(E), Section: B.

Thesis (Ph.D.)--Columbia University, 2013.

Plasmodium, like many other pathogenic organisms, relies on a balance of synthesis and scavenging of lipid species for replication. How the parasite creates this balance is particularly important to successfully intervene in transmission of the disease and to generate new chemotherapies to cure infections. This study focuses on two specific aspects in the field of lipid biology of Plasmodium parasites and their hosts. Lipoic acid is a short eight-carbon chain that serves a number of different functions with the cell. By disrupting a key enzyme in the lipoic acid synthesis pathway in the rodent species of malaria, Plasmodium berghei, we sought to investigate its role during the parasite life-cycle. Deletion of the lipoyl-octanoyl transferase enzyme, LipB in P. berghei parasites demonstrate a liver-stage specific need for this metabolic pathway. In order to explore the impact of the fatty acid and triglyceride content on the pathogenesis of Plasmodium parasites, this study tests two methods to reduce lipid content in vivo and test the propagation of P. berghei parasite in these environments. Results from this study set forth new avenues of research with implications for the development of novel antimalarials and vaccine candidates.

ISBN: 9781267812353Subjects--Topical Terms:

1017734
Biology, Microbiology.

Investigations into the metabolic requirements for lipoic acid and lipid species during the life cycle of the malarial parasite Plasmodium berghei.
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020 $a 9781267812353
035 $a (MiAaPQ)AAI3546949
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100 1 $a Falkard, Brie. $3 2101558
245 1 0 $a Investigations into the metabolic requirements for lipoic acid and lipid species during the life cycle of the malarial parasite Plasmodium berghei.
300 $a 176 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-04(E), Section: B.
500 $a Adviser: David Fidock.
502 $a Thesis (Ph.D.)--Columbia University, 2013.
520 $a Plasmodium, like many other pathogenic organisms, relies on a balance of synthesis and scavenging of lipid species for replication. How the parasite creates this balance is particularly important to successfully intervene in transmission of the disease and to generate new chemotherapies to cure infections. This study focuses on two specific aspects in the field of lipid biology of Plasmodium parasites and their hosts. Lipoic acid is a short eight-carbon chain that serves a number of different functions with the cell. By disrupting a key enzyme in the lipoic acid synthesis pathway in the rodent species of malaria, Plasmodium berghei, we sought to investigate its role during the parasite life-cycle. Deletion of the lipoyl-octanoyl transferase enzyme, LipB in P. berghei parasites demonstrate a liver-stage specific need for this metabolic pathway. In order to explore the impact of the fatty acid and triglyceride content on the pathogenesis of Plasmodium parasites, this study tests two methods to reduce lipid content in vivo and test the propagation of P. berghei parasite in these environments. Results from this study set forth new avenues of research with implications for the development of novel antimalarials and vaccine candidates.
590 $a School code: 0054.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Parasitology. $3 1028974
650 4 $a Chemistry, Biochemistry. $3 1017722
690 $a 0410
690 $a 0718
690 $a 0487
710 2 $a Columbia University. $b Microbiology, Immunology and Infection. $3 2091992
773 0 $t Dissertation Abstracts International $g 74-04B(E).
790 $a 0054
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3546949