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Xenoestrogen effects on fish: Molecu...

Osachoff, Heather Louise.

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Xenoestrogen effects on fish: Molecular to physiological approaches.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Xenoestrogen effects on fish: Molecular to physiological approaches./
Author:	Osachoff, Heather Louise.
Description:	282 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-07(E), Section: B.
Contained By:	Dissertation Abstracts International75-07B(E).
Subject:	Biology, Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NS23883
ISBN:	9780499238832

Xenoestrogen effects on fish: Molecular to physiological approaches.
Osachoff, Heather Louise.

Xenoestrogen effects on fish: Molecular to physiological approaches. - 282 p.

Source: Dissertation Abstracts International, Volume: 75-07(E), Section: B.

Thesis (Ph.D.)--Simon Fraser University (Canada), 2013.

Estrogen hormones, or compounds that mimic them (xenoestrogens), are found in surface waters worldwide mainly due to discharges to the environment from anthropogenic sources, such as sewage treatment plant (STP) effluents. Fish are adversely affected by these xenoestrogens in the areas of reproduction, growth, immune function and offspring fitness. To identify and explore the effects of xenoestrogens on salmonids, a series of toxicological studies were performed using comprehensive panels of assays evaluating immune, osmoregulatory, hematological, metabolic, reproductive and endocrine-related parameters in response to xenoestrogen- and STP effluent-exposures. Most studies included a post-treatment depuration phase to determine recovery timeframes of altered parameters.

ISBN: 9780499238832Subjects--Topical Terms:

1017816
Biology, Physiology.

Xenoestrogen effects on fish: Molecular to physiological approaches.
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020 $a 9780499238832
035 $a (MiAaPQ)AAINS23883
035 $a AAINS23883
040 $a MiAaPQ $c MiAaPQ
100 1 $a Osachoff, Heather Louise. $3 2101533
245 1 0 $a Xenoestrogen effects on fish: Molecular to physiological approaches.
300 $a 282 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-07(E), Section: B.
500 $a Advisers: Ronald C. Ydenberg; Christopher Kennedy.
502 $a Thesis (Ph.D.)--Simon Fraser University (Canada), 2013.
520 $a Estrogen hormones, or compounds that mimic them (xenoestrogens), are found in surface waters worldwide mainly due to discharges to the environment from anthropogenic sources, such as sewage treatment plant (STP) effluents. Fish are adversely affected by these xenoestrogens in the areas of reproduction, growth, immune function and offspring fitness. To identify and explore the effects of xenoestrogens on salmonids, a series of toxicological studies were performed using comprehensive panels of assays evaluating immune, osmoregulatory, hematological, metabolic, reproductive and endocrine-related parameters in response to xenoestrogen- and STP effluent-exposures. Most studies included a post-treatment depuration phase to determine recovery timeframes of altered parameters.
520 $a In male or juvenile fish, xenoestrogens are known to induce vitellogenesis, the mature female-related process of making eggs under estrogen receptor (ER) control that is initiated by the hepatic production of egg proteins, vitellogenin (VTG) and vitelline envelope proteins (VEPs). In three studies, induction of liver somatic index (LSI), plasma VTG protein or hepatic gene transcripts (ERs, VTG and VEPs) were found due to exposure to a tertiary-treated STP effluent, a synthetic wastewater, and estrogen hormones. In Rainbow trout exposed to xenoestrogens, LSI and transcripts recovered to baseline values after treatments ceased, while VTG protein concentrations remained elevated through recovery phases. Thus, gene expression alterations were only useful as indicators of existing exposure, while VTG protein levels were indicative of both present and prior exposure. Xenoestrogens affected several immune system functions, including reduced leukocyte counts, potentially increasing susceptibility to pathogens. Isolated leukocytes from head kidney and peripheral blood contained ERalpha and ERbeta transcripts, although only ERalpha1 and ERalpha2 were altered by xenoestrogen exposure, providing a direct mechanistic pathway for xenoestrogen modulation of the immune system. Reductions in burst swimming performance were found in Rainbow trout exposed to xenoestrogens, with potential mechanisms suggested involving altered osmoregulation (evidenced by reduced chloride ions) and decreased blood oxygen carrying capacity via a reduction in red blood cell counts. Overall, most but not all altered parameters recovered from exposure to xenoestrogens, and the adverse effects of environmentally-relevant concentrations of xenoestrogens on many biological functions showed that xenoestrogens pose a hazard to wild juvenile fish.
520 $a Keywords: Fish; estrogen hormone; toxicology; gene expression; sewage treatment plant effluent; vitellogenin.
590 $a School code: 0791.
650 4 $a Biology, Physiology. $3 1017816
650 4 $a Biology, Conservation. $3 1669964
650 4 $a Agriculture, Fisheries and Aquaculture. $3 1020913
650 4 $a Health Sciences, Toxicology. $3 1017752
650 4 $a Environmental Sciences. $3 676987
690 $a 0719
690 $a 0408
690 $a 0792
690 $a 0383
690 $a 0768
710 2 $a Simon Fraser University (Canada). $3 1020621
773 0 $t Dissertation Abstracts International $g 75-07B(E).
790 $a 0791
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NS23883