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Histone H2A-S122 is required for nuc...

Uffenbeck, Shannon R.

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Histone H2A-S122 is required for nuclear and mitochondrial genome stability.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Histone H2A-S122 is required for nuclear and mitochondrial genome stability./
作者:	Uffenbeck, Shannon R.
面頁冊數:	88 p.
附註:	Source: Dissertation Abstracts International, Volume: 75-01(E), Section: B.
Contained By:	Dissertation Abstracts International75-01B(E).
標題:	Biology, Molecular. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3594509
ISBN:	9781303390227

Histone H2A-S122 is required for nuclear and mitochondrial genome stability.
Uffenbeck, Shannon R.

Histone H2A-S122 is required for nuclear and mitochondrial genome stability. - 88 p.

Source: Dissertation Abstracts International, Volume: 75-01(E), Section: B.

Thesis (Ph.D.)--University of Alaska Fairbanks, 2013.

Organization and maintenance of the mitochondrial and nuclear genomes are vastly different, yet I have shown that a single serine in the H2A C-terminal tail (H2A-S122) is critical for stability of both genomes in the budding yeast, Saccharomyces cerevisiae. Phosphorylation of H2A-S122 has previously been implicated in the spindle assembly checkpoint (SAC), however I show that by mutating the serine to an alanine (H2A-S122A), the resulting aneuploidy occurs at a much higher rate than is observed by deleting its immediate downstream kinase BUB1. Furthermore, the H2A-S122A mutant displays an increased susceptibility to DNA damaging agents that is not observed in bubdelta1 deletion cells. Our studies also implicate H2A-S122 as critical to the maintenance of the mitochondrial genome, as upon introduction of the H2A-S122A mutation, cells rapidly lose their mitochondrial genomes.

ISBN: 9781303390227Subjects--Topical Terms:

1017719
Biology, Molecular.

Histone H2A-S122 is required for nuclear and mitochondrial genome stability.
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502 $a Thesis (Ph.D.)--University of Alaska Fairbanks, 2013.
520 $a Organization and maintenance of the mitochondrial and nuclear genomes are vastly different, yet I have shown that a single serine in the H2A C-terminal tail (H2A-S122) is critical for stability of both genomes in the budding yeast, Saccharomyces cerevisiae. Phosphorylation of H2A-S122 has previously been implicated in the spindle assembly checkpoint (SAC), however I show that by mutating the serine to an alanine (H2A-S122A), the resulting aneuploidy occurs at a much higher rate than is observed by deleting its immediate downstream kinase BUB1. Furthermore, the H2A-S122A mutant displays an increased susceptibility to DNA damaging agents that is not observed in bubdelta1 deletion cells. Our studies also implicate H2A-S122 as critical to the maintenance of the mitochondrial genome, as upon introduction of the H2A-S122A mutation, cells rapidly lose their mitochondrial genomes.
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