東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Hydrogen NMR spectroscopic analysis ...

Wang, Sidney.

Linked to FindBook

Google Book

Amazon

博客來

Hydrogen NMR spectroscopic analysis of colon adenocarcinoma metabolites.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Hydrogen NMR spectroscopic analysis of colon adenocarcinoma metabolites./
Author:	Wang, Sidney.
Description:	105 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 8720.
Contained By:	Dissertation Abstracts International71-02B.
Subject:	Biophysics, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3396030
ISBN:	9781109644524

Hydrogen NMR spectroscopic analysis of colon adenocarcinoma metabolites.
Wang, Sidney.

Hydrogen NMR spectroscopic analysis of colon adenocarcinoma metabolites. - 105 p.

Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 8720.

Thesis (Ph.D.)--Harvard University, 2010.

Paired samples of cancer and adjacent normal sections of colon tissue from colon adenocarcinoma patients were extracted by a methanol-chloroform-water mixture, partitioned into aqueous and organic phases, and subsequently examined by 1H NMR. Spectra were binned, normalized, and analyzed for significant statistical differences between normal and cancer groups. Principal component analysis and partial least squares discriminant analysis distinguished normal spectra from cancer with few false classifications for aqueous extractions, but were less successful in discriminating between normal and tumor tissues when applied to data acquired from organic extractions. Studies of organic spectra indicated that cholesterol, cholesterol esters, and phospholipids were elevated in cancer samples while triacylglycerol levels were depressed. Poly-unsaturated lipids also appeared predominantly in tumor biopsies, whereas mono-unsaturated lipids were more common in normal colon tissue. Analysis of aqueous samples showed increased quantities of uridine diphosphate N-acetyl-D-glucosamine, uracil, proline, lactate, O-phosphoethanolamine, glutamate, aspartate, oxidized glutathione, inosine monophosphate, and taurine in cancer spectra. In contrast, the metabolites glucose, myo-inositol, creatine, and scyllo-inositol were more prominent in normal spectra. The significant differences observed reflect normal and tumor cell metabolism in colon adenocarcinoma.

ISBN: 9781109644524Subjects--Topical Terms:

1019105
Biophysics, General.

Hydrogen NMR spectroscopic analysis of colon adenocarcinoma metabolites.
LDR:02303nam a2200265 4500 001 1964519
005 20141010092509.5
008 150210s2010 ||||||||||||||||| ||eng d
020 $a 9781109644524
035 $a (MiAaPQ)AAI3396030
035 $a AAI3396030
040 $a MiAaPQ $c MiAaPQ
100 1 $a Wang, Sidney. $3 2100984
245 1 0 $a Hydrogen NMR spectroscopic analysis of colon adenocarcinoma metabolites.
300 $a 105 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 8720.
500 $a Adviser: Julia Y. Wang.
502 $a Thesis (Ph.D.)--Harvard University, 2010.
520 $a Paired samples of cancer and adjacent normal sections of colon tissue from colon adenocarcinoma patients were extracted by a methanol-chloroform-water mixture, partitioned into aqueous and organic phases, and subsequently examined by 1H NMR. Spectra were binned, normalized, and analyzed for significant statistical differences between normal and cancer groups. Principal component analysis and partial least squares discriminant analysis distinguished normal spectra from cancer with few false classifications for aqueous extractions, but were less successful in discriminating between normal and tumor tissues when applied to data acquired from organic extractions. Studies of organic spectra indicated that cholesterol, cholesterol esters, and phospholipids were elevated in cancer samples while triacylglycerol levels were depressed. Poly-unsaturated lipids also appeared predominantly in tumor biopsies, whereas mono-unsaturated lipids were more common in normal colon tissue. Analysis of aqueous samples showed increased quantities of uridine diphosphate N-acetyl-D-glucosamine, uracil, proline, lactate, O-phosphoethanolamine, glutamate, aspartate, oxidized glutathione, inosine monophosphate, and taurine in cancer spectra. In contrast, the metabolites glucose, myo-inositol, creatine, and scyllo-inositol were more prominent in normal spectra. The significant differences observed reflect normal and tumor cell metabolism in colon adenocarcinoma.
590 $a School code: 0084.
650 4 $a Biophysics, General. $3 1019105
690 $a 0786
710 2 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 71-02B.
790 $a 0084
791 $a Ph.D.
792 $a 2010
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3396030