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Finding differential splice junction...

Tavakoli, Ahmad.

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Finding differential splice junctions in rna-seq data as transcriptional biomarkers for prostate cancer.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Finding differential splice junctions in rna-seq data as transcriptional biomarkers for prostate cancer./
作者:	Tavakoli, Ahmad.
面頁冊數:	113 p.
附註:	Source: Masters Abstracts International, Volume: 52-03.
Contained By:	Masters Abstracts International52-03(E).
標題:	Computer Science. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR87398
ISBN:	9780494873984

Finding differential splice junctions in rna-seq data as transcriptional biomarkers for prostate cancer.
Tavakoli, Ahmad.

Finding differential splice junctions in rna-seq data as transcriptional biomarkers for prostate cancer. - 113 p.

Source: Masters Abstracts International, Volume: 52-03.

Thesis (M.Sc.)--University of Windsor (Canada), 2013.

Alternative RNA splicing is a naturally occurring phenomenon that has been associated with different types of cancer. Detecting splice junctions in the genome of an organism is the key to the study of alternative splicing. RNA-Seq as a high-throughput sequencing technology has recently opened new horizons on the studying of various fields of transcriptomics, such as gene expression, chimeric events and alternative splicing.

ISBN: 9780494873984Subjects--Topical Terms:

626642
Computer Science.

Finding differential splice junctions in rna-seq data as transcriptional biomarkers for prostate cancer.
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245 1 0 $a Finding differential splice junctions in rna-seq data as transcriptional biomarkers for prostate cancer.
300 $a 113 p.
500 $a Source: Masters Abstracts International, Volume: 52-03.
500 $a Adviser: Luis G. Rueda.
502 $a Thesis (M.Sc.)--University of Windsor (Canada), 2013.
520 $a Alternative RNA splicing is a naturally occurring phenomenon that has been associated with different types of cancer. Detecting splice junctions in the genome of an organism is the key to the study of alternative splicing. RNA-Seq as a high-throughput sequencing technology has recently opened new horizons on the studying of various fields of transcriptomics, such as gene expression, chimeric events and alternative splicing.
520 $a In this research, we study prostate cancer from the viewpoint of splicing events as the second most common cancer in North America. We have proposed a method for differentially detecting splice junctions, and in a broader sense splice variants, from RNA-Seq data. We have designed a 2-D peak finding algorithm to combine and remove the dubious junctions across different samples of our population. A scoring mechanism is used to select junctions as features for prediction of cancer RNA-Seq data belonging to patients diagnosed with prostate cancer against benign samples. These junctions could be proposed as potential biomarkers for prostate cancer. We have employed support vector machines which proved to be highly successful in prediction of prostate cancer.
590 $a School code: 0115.
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650 4 $a Biology, Bioinformatics. $3 1018415
650 4 $a Health Sciences, Oncology. $3 1018566
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710 2 $a University of Windsor (Canada). $b COMPUTER SCIENCE. $3 2093677
773 0 $t Masters Abstracts International $g 52-03(E).
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793 $a English
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