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Genetic regulation of RNAi inheritan...

Buckley, Bethany.

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Genetic regulation of RNAi inheritance in the Caenorhabditis elegans germ line.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Genetic regulation of RNAi inheritance in the Caenorhabditis elegans germ line./
Author:	Buckley, Bethany.
Description:	159 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-08(E), Section: B.
Contained By:	Dissertation Abstracts International74-08B(E).
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3560561
ISBN:	9781303067709

Genetic regulation of RNAi inheritance in the Caenorhabditis elegans germ line.
Buckley, Bethany.

Genetic regulation of RNAi inheritance in the Caenorhabditis elegans germ line. - 159 p.

Source: Dissertation Abstracts International, Volume: 74-08(E), Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2013.

Small RNAs can regulate the expression of other cellular RNAs. RNA interference is a process by which small RNAs `silence' genes by inhibiting transcription or degrading messenger RNAs, preventing the gene from making functional products. RNAi induced silencing is epigenetic, the DNA sequence is left unaltered. Interestingly, RNAi induced silencing can be heritable for multiple generations. The nematode C. elegans is the perfect model for studying this epigenetic phenomenon C. elegans are amenable to RNAi and RNAi induced silencing of genes in the germ line can be heritable for many (>10) generations. This thesis aims to better understand the mechanism and genetics of RNAi inheritance in the C. elegans germ line. Chapter 2 of this thesis presents the identification of a novel nuclear Ago that promotes germline RNAi inheritance. Chapter 2 also highlights the importance of nuclear silencing in multigenerational RNAi inheritance and suggests that heterochromatin and siRNAs might act as heritable agents of RNAi memory. RNAi inheritance does not last forever. Chapter 3 explores the idea that the reason RNAi inheritance does not last forever might be because it is under negative regulation. Chapter 3 presents preliminary results from a forward genetic screen that was conducted to identify mutants in which RNAi inheritance is no longer limited and RNAi silencing can essentially become permanent.

ISBN: 9781303067709Subjects--Topical Terms:

1017730
Biology, Genetics.

Genetic regulation of RNAi inheritance in the Caenorhabditis elegans germ line.
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100 1 $a Buckley, Bethany. $3 2099930
245 1 0 $a Genetic regulation of RNAi inheritance in the Caenorhabditis elegans germ line.
300 $a 159 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-08(E), Section: B.
500 $a Adviser: Scott Kennedy.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2013.
520 $a Small RNAs can regulate the expression of other cellular RNAs. RNA interference is a process by which small RNAs `silence' genes by inhibiting transcription or degrading messenger RNAs, preventing the gene from making functional products. RNAi induced silencing is epigenetic, the DNA sequence is left unaltered. Interestingly, RNAi induced silencing can be heritable for multiple generations. The nematode C. elegans is the perfect model for studying this epigenetic phenomenon C. elegans are amenable to RNAi and RNAi induced silencing of genes in the germ line can be heritable for many (>10) generations. This thesis aims to better understand the mechanism and genetics of RNAi inheritance in the C. elegans germ line. Chapter 2 of this thesis presents the identification of a novel nuclear Ago that promotes germline RNAi inheritance. Chapter 2 also highlights the importance of nuclear silencing in multigenerational RNAi inheritance and suggests that heterochromatin and siRNAs might act as heritable agents of RNAi memory. RNAi inheritance does not last forever. Chapter 3 explores the idea that the reason RNAi inheritance does not last forever might be because it is under negative regulation. Chapter 3 presents preliminary results from a forward genetic screen that was conducted to identify mutants in which RNAi inheritance is no longer limited and RNAi silencing can essentially become permanent.
590 $a School code: 0262.
650 4 $a Biology, Genetics. $3 1017730
690 $a 0369
710 2 $a The University of Wisconsin - Madison. $b Genetics. $3 2099931
773 0 $t Dissertation Abstracts International $g 74-08B(E).
790 $a 0262
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3560561