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Investigation of bacterial rna-direc...

Li, Dandan.

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Investigation of bacterial rna-directed DNA methylation via Dcm and Hfq.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Investigation of bacterial rna-directed DNA methylation via Dcm and Hfq./
作者:	Li, Dandan.
面頁冊數:	87 p.
附註:	Source: Masters Abstracts International, Volume: 51-06.
Contained By:	Masters Abstracts International51-06(E).
標題:	Biology, Molecular. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1537536
ISBN:	9781303087202

Investigation of bacterial rna-directed DNA methylation via Dcm and Hfq.
Li, Dandan.

Investigation of bacterial rna-directed DNA methylation via Dcm and Hfq. - 87 p.

Source: Masters Abstracts International, Volume: 51-06.

Thesis (M.S.)--Wayne State University, 2013.

Bacterial small RNAs and the RNA chaperone Hfq play crucial roles in post-transcriptional gene regulation, often as parts of stress-response pathways, but little is known about their roles in regulation of gene transcription. A recent report showed that changes in methylation patterns caused by DNA cytosine methyltransferase (Dcm) were linked to gene regulation occurring during the transition to stationary phase. Here, we show that Dcm involves in the stress responses under nutrient starvation and cold stress. Dcm and Hfq together mediate gene expression under cold stress. Hfq promotes Dcm-catalyzed cytosine methylation at specific sites near the rpoS promoter, which is consistent with the genome-wide analysis and linking known stress response pathways to altered methylation. Overexpressing DsrA, an sRNA induced at low temperature to regulate genes required for cold adaptation, stimulates this DNA methylation behavior, showing that the regulation is sRNA-dependent. This represents the first example of an RNA-directed DNA methylation mechanism in bacteria responsible for modulating gene expression.

ISBN: 9781303087202Subjects--Topical Terms:

1017719
Biology, Molecular.

Investigation of bacterial rna-directed DNA methylation via Dcm and Hfq.
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520 $a Bacterial small RNAs and the RNA chaperone Hfq play crucial roles in post-transcriptional gene regulation, often as parts of stress-response pathways, but little is known about their roles in regulation of gene transcription. A recent report showed that changes in methylation patterns caused by DNA cytosine methyltransferase (Dcm) were linked to gene regulation occurring during the transition to stationary phase. Here, we show that Dcm involves in the stress responses under nutrient starvation and cold stress. Dcm and Hfq together mediate gene expression under cold stress. Hfq promotes Dcm-catalyzed cytosine methylation at specific sites near the rpoS promoter, which is consistent with the genome-wide analysis and linking known stress response pathways to altered methylation. Overexpressing DsrA, an sRNA induced at low temperature to regulate genes required for cold adaptation, stimulates this DNA methylation behavior, showing that the regulation is sRNA-dependent. This represents the first example of an RNA-directed DNA methylation mechanism in bacteria responsible for modulating gene expression.
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