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Investigation of bacterial rna-direc...

Li, Dandan.

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Investigation of bacterial rna-directed DNA methylation via Dcm and Hfq.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Investigation of bacterial rna-directed DNA methylation via Dcm and Hfq./
Author:	Li, Dandan.
Description:	87 p.
Notes:	Source: Masters Abstracts International, Volume: 51-06.
Contained By:	Masters Abstracts International51-06(E).
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1537536
ISBN:	9781303087202

Investigation of bacterial rna-directed DNA methylation via Dcm and Hfq.
Li, Dandan.

Investigation of bacterial rna-directed DNA methylation via Dcm and Hfq. - 87 p.

Source: Masters Abstracts International, Volume: 51-06.

Thesis (M.S.)--Wayne State University, 2013.

Bacterial small RNAs and the RNA chaperone Hfq play crucial roles in post-transcriptional gene regulation, often as parts of stress-response pathways, but little is known about their roles in regulation of gene transcription. A recent report showed that changes in methylation patterns caused by DNA cytosine methyltransferase (Dcm) were linked to gene regulation occurring during the transition to stationary phase. Here, we show that Dcm involves in the stress responses under nutrient starvation and cold stress. Dcm and Hfq together mediate gene expression under cold stress. Hfq promotes Dcm-catalyzed cytosine methylation at specific sites near the rpoS promoter, which is consistent with the genome-wide analysis and linking known stress response pathways to altered methylation. Overexpressing DsrA, an sRNA induced at low temperature to regulate genes required for cold adaptation, stimulates this DNA methylation behavior, showing that the regulation is sRNA-dependent. This represents the first example of an RNA-directed DNA methylation mechanism in bacteria responsible for modulating gene expression.

ISBN: 9781303087202Subjects--Topical Terms:

1017719
Biology, Molecular.

Investigation of bacterial rna-directed DNA methylation via Dcm and Hfq.
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020 $a 9781303087202
035 $a (MiAaPQ)AAI1537536
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100 1 $a Li, Dandan. $3 2099845
245 1 0 $a Investigation of bacterial rna-directed DNA methylation via Dcm and Hfq.
300 $a 87 p.
500 $a Source: Masters Abstracts International, Volume: 51-06.
500 $a Adviser: Andrew Feig.
502 $a Thesis (M.S.)--Wayne State University, 2013.
520 $a Bacterial small RNAs and the RNA chaperone Hfq play crucial roles in post-transcriptional gene regulation, often as parts of stress-response pathways, but little is known about their roles in regulation of gene transcription. A recent report showed that changes in methylation patterns caused by DNA cytosine methyltransferase (Dcm) were linked to gene regulation occurring during the transition to stationary phase. Here, we show that Dcm involves in the stress responses under nutrient starvation and cold stress. Dcm and Hfq together mediate gene expression under cold stress. Hfq promotes Dcm-catalyzed cytosine methylation at specific sites near the rpoS promoter, which is consistent with the genome-wide analysis and linking known stress response pathways to altered methylation. Overexpressing DsrA, an sRNA induced at low temperature to regulate genes required for cold adaptation, stimulates this DNA methylation behavior, showing that the regulation is sRNA-dependent. This represents the first example of an RNA-directed DNA methylation mechanism in bacteria responsible for modulating gene expression.
590 $a School code: 0254.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Biology, Genetics. $3 1017730
690 $a 0307
690 $a 0487
690 $a 0369
710 2 $a Wayne State University. $b Chemistry. $3 1024015
773 0 $t Masters Abstracts International $g 51-06(E).
790 $a 0254
791 $a M.S.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1537536