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Wireless neural recording and stimul...

Abdelhalim, Karim.

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Wireless neural recording and stimulation SoCs for monitoring and treatment of intractable epilepsy.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Wireless neural recording and stimulation SoCs for monitoring and treatment of intractable epilepsy./
Author:	Abdelhalim, Karim.
Description:	243 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-05(E), Section: B.
Contained By:	Dissertation Abstracts International75-05B(E).
Subject:	Engineering, Computer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NS22004
ISBN:	9780499220042

Wireless neural recording and stimulation SoCs for monitoring and treatment of intractable epilepsy.
Abdelhalim, Karim.

Wireless neural recording and stimulation SoCs for monitoring and treatment of intractable epilepsy. - 243 p.

Source: Dissertation Abstracts International, Volume: 75-05(E), Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2013.

This dissertation presents the system architecture and implementation of two wireless systems-on-chip (SoCs) for diagnostics and treatment of neurological disorders. It also validates the SoCs as an electronic implant for preoperative monitoring and treatment of intractable epilepsy.

ISBN: 9780499220042Subjects--Topical Terms:

1669061
Engineering, Computer.

Wireless neural recording and stimulation SoCs for monitoring and treatment of intractable epilepsy.
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100 1 $a Abdelhalim, Karim. $3 1058500
245 1 0 $a Wireless neural recording and stimulation SoCs for monitoring and treatment of intractable epilepsy.
300 $a 243 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-05(E), Section: B.
500 $a Adviser: Roman Genov.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2013.
520 $a This dissertation presents the system architecture and implementation of two wireless systems-on-chip (SoCs) for diagnostics and treatment of neurological disorders. It also validates the SoCs as an electronic implant for preoperative monitoring and treatment of intractable epilepsy.
520 $a The first prototype SoC is a neural recording interface intended for wireless monitoring of intractable epilepsy. The 0.13microm CMOS SoC has 64 recording channels, 64 programmable FIR filters and an integrated 915MHz FSK PLL-based wireless transmitter. Each channel contains a low-noise amplifier and a modified 8-bit SAR ADC that and can provide analog-digital multiplication by modifying the ADC sampling phase. It is used in conjunction with 12-bit digital adders and registers to implement 64 16-tap FIR filters with a minimal area and power overhead. In vivo measurement results from freely moving rodents demonstrate its utility in preoperative monitoring epileptic seizures.
520 $a Treatment of intractable epilepsy by responsive neurostimulation requires seizure detection capabilities. Next, a low-power VLSI processor architecture for early seizure detection is described. It the magnitude, phase and phase synchronization of two neural signals---all precursors of a seizure. The processor is utilized in an implantable responsive neural stimulator application. The architecture uses three CORDIC processing cores that require shift-and-add operations but no multiplication. The efficacy of the processor in epileptic seizure detection is validated on human EEG data and yields comparable performance to software-based algorithms.
520 $a The second prototype SoC is a closed-loop 64-channel neural stimulator that includes the aforementioned seizure detector processor and is used for preventive seizure abortion. It constitutes a neural vector analyzer that monitors the magnitude, phase and phase synchronization of neural signals to enable seizure detection. In a closed loop, abnormal phase synchrony triggers the programmable-waveform biphasic neural stimulator. To implement these functionalities, the 0.13microm CMOS SoC integrates 64 amplifiers with switched-capacitor (SC) bandpass filters, 64 MADCs, 64 16-tap FIR filters, a processor, 64 biphasic stimulators and a wireless transmitter. The SoC is validated in the detection and abortion of seizures in freely moving rodents on-line and in early seizure detection in humans off-line. The results demonstrate its utility in treatment of intractable epilepsy.
590 $a School code: 0779.
650 4 $a Engineering, Computer. $3 1669061
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Biology, Neuroscience. $3 1017680
690 $a 0464
690 $a 0541
690 $a 0317
710 2 $a University of Toronto (Canada). $b Electrical and Computer Engineering. $3 2096349
773 0 $t Dissertation Abstracts International $g 75-05B(E).
790 $a 0779
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NS22004