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Synthesis of Diphenylalanine-Guanosi...

Lusk, Jason Scott.

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Synthesis of Diphenylalanine-Guanosine Adducts and Investigation of Their Self Assembly Properties.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Synthesis of Diphenylalanine-Guanosine Adducts and Investigation of Their Self Assembly Properties./
Author:	Lusk, Jason Scott.
Description:	208 p.
Notes:	Source: Masters Abstracts International, Volume: 51-05.
Contained By:	Masters Abstracts International51-05(E).
Subject:	Chemistry, Organic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1534498
ISBN:	9781267944993

Synthesis of Diphenylalanine-Guanosine Adducts and Investigation of Their Self Assembly Properties.
Lusk, Jason Scott.

Synthesis of Diphenylalanine-Guanosine Adducts and Investigation of Their Self Assembly Properties. - 208 p.

Source: Masters Abstracts International, Volume: 51-05.

Thesis (M.S.)--University of California, Irvine, 2013.

Nature is replete with supramolecular structures involving weak interactions. For example, guanine, in the presence of a suitable cation, forms stacked structures known as "G-quadruplexes," while diphenylalanine may aggregate via pi-pi stacking into structures that display quantum dot properties. To this end, an series of adducts of guanosine and diphenylalanine have been synthesized and studied to determine the effect that G-quadruplex formation might have on quantum dot assembly. Circular dichroism and proton NMR studies confirm the ability of these adducts to form G-quadruplexes in non-polar solvents; furthermore, it is demonstrated that quadruplex formation is highly dependent upon the presence of potassium cations, and that quadruplex assembly is reversed if potassium ions are "trapped" by 18-crown-6. Atomic force microscopy and photoluminescence excitation spectroscopy confirm that the adducts synthesized form peptide quantum dots in protic and polar aprotic solvents. At the present, the formation of G-quadruplexes has no apparent effect on peptide quantum dot assembly or activity.

ISBN: 9781267944993Subjects--Topical Terms:

516206
Chemistry, Organic.

Synthesis of Diphenylalanine-Guanosine Adducts and Investigation of Their Self Assembly Properties.
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100 1 $a Lusk, Jason Scott. $3 2096024
245 1 0 $a Synthesis of Diphenylalanine-Guanosine Adducts and Investigation of Their Self Assembly Properties.
300 $a 208 p.
500 $a Source: Masters Abstracts International, Volume: 51-05.
500 $a Adviser: Zhibin Guan.
502 $a Thesis (M.S.)--University of California, Irvine, 2013.
520 $a Nature is replete with supramolecular structures involving weak interactions. For example, guanine, in the presence of a suitable cation, forms stacked structures known as "G-quadruplexes," while diphenylalanine may aggregate via pi-pi stacking into structures that display quantum dot properties. To this end, an series of adducts of guanosine and diphenylalanine have been synthesized and studied to determine the effect that G-quadruplex formation might have on quantum dot assembly. Circular dichroism and proton NMR studies confirm the ability of these adducts to form G-quadruplexes in non-polar solvents; furthermore, it is demonstrated that quadruplex formation is highly dependent upon the presence of potassium cations, and that quadruplex assembly is reversed if potassium ions are "trapped" by 18-crown-6. Atomic force microscopy and photoluminescence excitation spectroscopy confirm that the adducts synthesized form peptide quantum dots in protic and polar aprotic solvents. At the present, the formation of G-quadruplexes has no apparent effect on peptide quantum dot assembly or activity.
590 $a School code: 0030.
650 4 $a Chemistry, Organic. $3 516206
650 4 $a Chemistry, General. $3 1021807
690 $a 0490
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710 2 $a University of California, Irvine. $b Chemistry - M.S.. $3 2096025
773 0 $t Masters Abstracts International $g 51-05(E).
790 $a 0030
791 $a M.S.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1534498