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Functionalizable biodegradable polye...

Banerjee, Abhishek.

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Functionalizable biodegradable polyesters for drug delivery applications.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Functionalizable biodegradable polyesters for drug delivery applications./
作者:	Banerjee, Abhishek.
面頁冊數:	186 p.
附註:	Source: Dissertation Abstracts International, Volume: 73-11(E), Section: B.
Contained By:	Dissertation Abstracts International73-11B(E).
標題:	Chemistry, Polymer. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3516054
ISBN:	9781267440167

Functionalizable biodegradable polyesters for drug delivery applications.
Banerjee, Abhishek.

Functionalizable biodegradable polyesters for drug delivery applications. - 186 p.

Source: Dissertation Abstracts International, Volume: 73-11(E), Section: B.

Thesis (Ph.D.)--The University of Akron, 2012.

Current biodegradable polymers, like poly(lactic acid) (PLA), poly(glycolic acid) (PGA) and their copolymers (PLGA) do not have functionalities on their backbones. Such biodegradable polymer systems are therefore not able to covalently attach drugs or other therapeutic molecules, which could be useful for making drug delivery devices. Instead, the therapeutic molecules must be physically entrapped into these polymers, either by forming micelles or by nano-encapsulation, thereby limiting their loading capacity.

ISBN: 9781267440167Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Functionalizable biodegradable polyesters for drug delivery applications.
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245 1 0 $a Functionalizable biodegradable polyesters for drug delivery applications.
300 $a 186 p.
500 $a Source: Dissertation Abstracts International, Volume: 73-11(E), Section: B.
500 $a Advisers: Coleen Pugh; Li Jia.
502 $a Thesis (Ph.D.)--The University of Akron, 2012.
520 $a Current biodegradable polymers, like poly(lactic acid) (PLA), poly(glycolic acid) (PGA) and their copolymers (PLGA) do not have functionalities on their backbones. Such biodegradable polymer systems are therefore not able to covalently attach drugs or other therapeutic molecules, which could be useful for making drug delivery devices. Instead, the therapeutic molecules must be physically entrapped into these polymers, either by forming micelles or by nano-encapsulation, thereby limiting their loading capacity.
520 $a Our research deals with the polyesterification of 2-bromo-3-hydroxypropanoic acid which is a halogenated isomer of lactic acid, yet has a primary alcohol group like glycolic acid. It is therefore an ideal co-monomer for incorporation into PLGA. Such co-polyesters are potentially biodegradable with halogen functionalities on the main chain. We have synthesized brominated copolymers with LA and GA of number average molecular weights around 20,000 Da (PS standards), under bulk co-polymerization conditions. The number of functionalizable sites on the main chain of this polyester is controlled by varying the feed ratio of the halogen co-monomer. The biodegradability of the polymer can also be tailored by varying the lactic acid and glycolic acid feed ratios. Solution polymerization using carbodiimide chemistry at room temperature has also been explored to prepare these co-polymers, with lesser success.
520 $a The biodegradation behavior of these brominated polyesters were studied in the form of compression molded tablets under physiological conditions, Phosphate buffer saline (pH 7.4), at 37 °C and these polymers were found to degrade to around 80% of their initial molecular weights.
590 $a School code: 0003.
650 4 $a Chemistry, Polymer. $3 1018428
690 $a 0495
710 2 $a The University of Akron. $b Polymer Science. $3 2094124
773 0 $t Dissertation Abstracts International $g 73-11B(E).
790 $a 0003
791 $a Ph.D.
792 $a 2012
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3516054