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Broad-spectrum antibacterial propert...

Ottomeyer, Megan.

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Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications./
Author:	Ottomeyer, Megan.
Description:	56 p.
Notes:	Source: Masters Abstracts International, Volume: 52-02.
Contained By:	Masters Abstracts International52-02(E).
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1523724
ISBN:	9781303352430

Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications.
Ottomeyer, Megan.

Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications. - 56 p.

Source: Masters Abstracts International, Volume: 52-02.

Thesis (M.S.)--Missouri University of Science and Technology, 2013.

Bioactive glasses with antimicrobial properties can be implemented as coatings on medical devices and implants, as well as a treatment for tissue repair and prevention of common hospital-acquired infections such as MRSA. A borate-containing glass, B3, is also undergoing clinical trials to assess wound-healing properties. The sensitivities of various bacteria to B3, B3-Ag, B3-Ga, and B3-I bioactive glasses were tested. In addition, the mechanism of action for the glasses was studied by spectroscopic enzyme kinetics experiments, Live-Dead staining fluorescence microscopy, and luminescence assays using two gene fusion strains of Escherichia coli.

ISBN: 9781303352430Subjects--Topical Terms:

1017734
Biology, Microbiology.

Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications.
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020 $a 9781303352430
035 $a (MiAaPQ)AAI1523724
035 $a AAI1523724
040 $a MiAaPQ $c MiAaPQ
100 1 $a Ottomeyer, Megan. $3 2094065
245 1 0 $a Broad-spectrum antibacterial properties of metal-ion doped borate bioactive glasses for clinical applications.
300 $a 56 p.
500 $a Source: Masters Abstracts International, Volume: 52-02.
500 $a Adviser: David Westenberg.
502 $a Thesis (M.S.)--Missouri University of Science and Technology, 2013.
520 $a Bioactive glasses with antimicrobial properties can be implemented as coatings on medical devices and implants, as well as a treatment for tissue repair and prevention of common hospital-acquired infections such as MRSA. A borate-containing glass, B3, is also undergoing clinical trials to assess wound-healing properties. The sensitivities of various bacteria to B3, B3-Ag, B3-Ga, and B3-I bioactive glasses were tested. In addition, the mechanism of action for the glasses was studied by spectroscopic enzyme kinetics experiments, Live-Dead staining fluorescence microscopy, and luminescence assays using two gene fusion strains of Escherichia coli.
520 $a It was found that gram-positive bacteria were more sensitive to all four glasses than gram negative bacteria, and that a single mechanism of action for the glasses is unlikely, as the rates of catalysis for metabolic enzymes as well as membrane permeability were altered after glass exposure.
590 $a School code: 0587.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Engineering, Materials Science. $3 1017759
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
690 $a 0410
690 $a 0794
690 $a 0564
710 2 $a Missouri University of Science and Technology. $b Applied and Environmental Biology. $3 2094066
773 0 $t Masters Abstracts International $g 52-02(E).
790 $a 0587
791 $a M.S.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1523724