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Coupled Effects of Mechanics, Geomet...

Giang, Ha.

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Coupled Effects of Mechanics, Geometry, and Chemistry on Bio-membrane Behavior.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Coupled Effects of Mechanics, Geometry, and Chemistry on Bio-membrane Behavior./
Author:	Giang, Ha.
Description:	135 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.
Contained By:	Dissertation Abstracts International74-10B(E).
Subject:	Biophysics, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3565136
ISBN:	9781303146480

Coupled Effects of Mechanics, Geometry, and Chemistry on Bio-membrane Behavior.
Giang, Ha.

Coupled Effects of Mechanics, Geometry, and Chemistry on Bio-membrane Behavior. - 135 p.

Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.

Thesis (Ph.D.)--California Institute of Technology, 2013.

Lipid bilayer membranes are models for cell membranes--the structure that helps regulate cell function. Cell membranes are heterogeneous, and the coupling between composition and shape gives rise to complex behaviors that are important to regulation. This thesis seeks to systematically build and analyze complete models to understand the behavior of multi-component membranes.

ISBN: 9781303146480Subjects--Topical Terms:

1019105
Biophysics, General.

Coupled Effects of Mechanics, Geometry, and Chemistry on Bio-membrane Behavior.
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100 1 $a Giang, Ha. $3 2093118
245 1 0 $a Coupled Effects of Mechanics, Geometry, and Chemistry on Bio-membrane Behavior.
300 $a 135 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.
500 $a Adviser: Kaushik Bhattacharya.
502 $a Thesis (Ph.D.)--California Institute of Technology, 2013.
520 $a Lipid bilayer membranes are models for cell membranes--the structure that helps regulate cell function. Cell membranes are heterogeneous, and the coupling between composition and shape gives rise to complex behaviors that are important to regulation. This thesis seeks to systematically build and analyze complete models to understand the behavior of multi-component membranes.
520 $a We propose a model and use it to derive the equilibrium and stability conditions for a general class of closed multi-component biological membranes. Our analysis shows that the critical modes of these membranes have high frequencies, unlike single-component vesicles, and their stability depends on system size, unlike in systems undergoing spinodal decomposition in flat space. An important implication is that small perturbations may nucleate localized but very large deformations. We compare these results with experimental observations.
520 $a We also study open membranes to gain insight into long tubular membranes that arise for example in nerve cells. We derive a complete system of equations for open membranes by using the principle of virtual work. Our linear stability analysis predicts that the tubular membranes tend to have coiling shapes if the tension is small, cylindrical shapes if the tension is moderate, and beading shapes if the tension is large. This is consistent with experimental observations reported in the literature in nerve fibers. Further, we provide numerical solutions to the fully nonlinear equilibrium equations in some problems, and show that the observed mode shapes are consistent with those suggested by linear stability. Our work also proves that beadings of nerve fibers can appear purely as a mechanical response of the membrane.
590 $a School code: 0037.
650 4 $a Biophysics, General. $3 1019105
650 4 $a Engineering, Mechanical. $3 783786
650 4 $a Applied Mathematics. $3 1669109
650 4 $a Chemistry, Biochemistry. $3 1017722
690 $a 0786
690 $a 0548
690 $a 0364
690 $a 0487
710 2 $a California Institute of Technology. $b Mechanical Engineering. $3 2093076
773 0 $t Dissertation Abstracts International $g 74-10B(E).
790 $a 0037
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3565136