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Evaluation of Immune Management Stra...

Linhares, Daniel Correia Lima.

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Evaluation of Immune Management Strategies to Control and Eliminate Porcine Reproductive and Respiratory Syndrome Virus (PRRSv).

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Evaluation of Immune Management Strategies to Control and Eliminate Porcine Reproductive and Respiratory Syndrome Virus (PRRSv)./
Author:	Linhares, Daniel Correia Lima.
Description:	148 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-07(E), Section: B.
Contained By:	Dissertation Abstracts International74-07B(E).
Subject:	Biology, Veterinary Science. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3556102
ISBN:	9781267978325

Evaluation of Immune Management Strategies to Control and Eliminate Porcine Reproductive and Respiratory Syndrome Virus (PRRSv).
Linhares, Daniel Correia Lima.

Evaluation of Immune Management Strategies to Control and Eliminate Porcine Reproductive and Respiratory Syndrome Virus (PRRSv). - 148 p.

Source: Dissertation Abstracts International, Volume: 74-07(E), Section: B.

Thesis (Ph.D.)--University of Minnesota, 2013.

Porcine reproductive and respiratory syndrome (PRRS) is an infectious disease caused by PRRS virus (PRRSv). PRRSv is considered one of the most economically important infectious agents in the swine industry worldwide. This thesis evaluated immune management strategies to eliminate PRRSv from breeding herds, assessed the impact of those strategies in production losses, evaluated management risk factors associated with successful PRRSv elimination or failure, and lastly evaluated vaccination as means to reduce virus dissemination from infected growing pig populations.

ISBN: 9781267978325Subjects--Topical Terms:

1021733
Biology, Veterinary Science.

Evaluation of Immune Management Strategies to Control and Eliminate Porcine Reproductive and Respiratory Syndrome Virus (PRRSv).
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020 $a 9781267978325
035 $a (MiAaPQ)AAI3556102
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100 1 $a Linhares, Daniel Correia Lima. $3 2093077
245 1 0 $a Evaluation of Immune Management Strategies to Control and Eliminate Porcine Reproductive and Respiratory Syndrome Virus (PRRSv).
300 $a 148 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-07(E), Section: B.
500 $a Adviser: Montserrat Torremorell.
502 $a Thesis (Ph.D.)--University of Minnesota, 2013.
520 $a Porcine reproductive and respiratory syndrome (PRRS) is an infectious disease caused by PRRS virus (PRRSv). PRRSv is considered one of the most economically important infectious agents in the swine industry worldwide. This thesis evaluated immune management strategies to eliminate PRRSv from breeding herds, assessed the impact of those strategies in production losses, evaluated management risk factors associated with successful PRRSv elimination or failure, and lastly evaluated vaccination as means to reduce virus dissemination from infected growing pig populations.
520 $a Chapter 2 compared the use of two immunogens as part of load-close-expose programs in regards to the time it takes to reach PRRSv stability (TTS) from infected breeding herds. Results showed that despite the great variability of TTS between enrolled herds, there were some variables associated with shorter TTS. Specifically, herds that used LVI as the method of whole-herd exposure reached TTS earlier than herds that used MLV vaccines. Moreover, herds with history of PRRSv infection in the 3 years prior to our study reached TTS sooner than herds without history of PRRSv in those same 3 years. Furthermore, herds assisted by a specific veterinary clinic reached TTS sooner than all other herds suggesting that there might be management practices associated with shorter TTS. Our results also showed that PRRSv-monitoring must be done repeatedly over time to increase confidence of PRRSv-negative status of weaned piglets. Altogether, those findings represent prove of concept that herds can reach PRRSv stability as soon as 84 days from establishment of LCE. Further studies are needed to better understand specific factors associated with reaching short TTS, such as farm layout, pig flow and implementation of specific management practices during the period of herd closure.
520 $a Chapter 3 evaluated the effect of attenuated PRRSv vaccine inoculation compared to the use of live-virulent virus inoculation on production performance in breeding herds. It was shown that herds that used MLV vaccine as part of load-close-expose herd closure programs recovered production levels and had a less severe production impact than herds that used LVI. Also, herds that reported previous PRRSv infection reached time to baseline production (TTBP) sooner than herds with no history of PRRSv infection in the previous 3 years. Interestingly, herds assisted by a specific veterinary clinic recovered production faster than other herds, raising the hypothesis that specific management practices could be associated with herd closure effectiveness.
520 $a Chapter 4 was a follow-up from the previous 2 chapters and investigated herd-closure practices associated with successful PRRSv-elimination from breeding herds. It showed that the success rate of LCE programs was 76% and 92% for LVI and MLV herds, when failures associated with unrelated PRRSv were excluded from the analysis although these differences were not statistically significant. Moreover, one out of six herds that achieved 90 days of failure to detect PRRSv in due to wean piglets failed to achieve AASV category III, which indicates that more strict monitoring programs should be adopted in herds undergoing PRRSv elimination. Interestingly, herds assisted by different veterinary clinics had different set of recommendations of management practices to be followed during LCE, indicating that there was no agreement between veterinarians on what is the relative importance of each management practice evaluated. The variables associated with failure to reach AASV category III were a) being infected with a PRRSv of RFLP pattern 1-4-4 and b) holding back pigs at weaning for quality.
520 $a Chapter 5 focused on PRRSv-infected growing pig populations. Growing pig populations are a major source of PRRSv dissemination within regions. The effect of an attenuated PRRSv vaccine was evaluated on shedding and generation of aerosols of a wild-type virus from an infected growing pig population raised under Minnesota's swine industry field conditions. Our results showed that vaccinating acutely PRRSv infected growing pigs with MLV vaccine reduced duration and magnitude of PRRSv detection in aerosols exhausted from the pig barn. (Abstract shortened by UMI.).
590 $a School code: 0130.
650 4 $a Biology, Veterinary Science. $3 1021733
650 4 $a Agriculture, Animal Pathology. $3 1021764
690 $a 0778
690 $a 0476
710 2 $a University of Minnesota. $b Veterinary Medicine. $3 1682756
773 0 $t Dissertation Abstracts International $g 74-07B(E).
790 $a 0130
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3556102