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Empirical bayes variable selection i...

Pungpapong, Vitara.

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Empirical bayes variable selection in high-dimensional regression.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Empirical bayes variable selection in high-dimensional regression./
Author:	Pungpapong, Vitara.
Description:	121 p.
Notes:	Source: Dissertation Abstracts International, Volume: 74-04(E), Section: B.
Contained By:	Dissertation Abstracts International74-04B(E).
Subject:	Statistics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3545358
ISBN:	9781267775795

Empirical bayes variable selection in high-dimensional regression.
Pungpapong, Vitara.

Empirical bayes variable selection in high-dimensional regression. - 121 p.

Source: Dissertation Abstracts International, Volume: 74-04(E), Section: B.

Thesis (Ph.D.)--Purdue University, 2012.

Available high-throughput biotechnologies make it necessary to select important candidates out of massive biomarkers while exploiting their complicated relationship structures. Here we consider an empirical Bayes method for variable selection in regression models. In most practical situations, Markov chain Monte Carlo (MCMC) algorithms are used for implementation by many previous empirical Bayes variable selection methods. However, these MCMC based procedures are challenged by exponentially growing numbers of biomarkers and involve intensive computing. We propose an iterated conditional modes/medians (ICM/M) algorithm which will be employed to implement an empirical Bayes variable selection in regression models. First, iterative conditional modes are employed to optimize values of the hyperparameters so as to implement the empirical Bayes method; Second, iterative conditional medians are used to estimate the model coefficients and therefore implement the variable selection function. Our simulation studies suggest fast computation and superior performance of the proposed method. The developed algorithm has also been applied to real omics data.

ISBN: 9781267775795Subjects--Topical Terms:

517247
Statistics.

Empirical bayes variable selection in high-dimensional regression.
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020 $a 9781267775795
035 $a (UMI)AAI3545358
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040 $a UMI $c UMI
100 1 $a Pungpapong, Vitara. $3 2092567
245 1 0 $a Empirical bayes variable selection in high-dimensional regression.
300 $a 121 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-04(E), Section: B.
500 $a Advisers: Dabao Zhang; Min Zhang.
502 $a Thesis (Ph.D.)--Purdue University, 2012.
520 $a Available high-throughput biotechnologies make it necessary to select important candidates out of massive biomarkers while exploiting their complicated relationship structures. Here we consider an empirical Bayes method for variable selection in regression models. In most practical situations, Markov chain Monte Carlo (MCMC) algorithms are used for implementation by many previous empirical Bayes variable selection methods. However, these MCMC based procedures are challenged by exponentially growing numbers of biomarkers and involve intensive computing. We propose an iterated conditional modes/medians (ICM/M) algorithm which will be employed to implement an empirical Bayes variable selection in regression models. First, iterative conditional modes are employed to optimize values of the hyperparameters so as to implement the empirical Bayes method; Second, iterative conditional medians are used to estimate the model coefficients and therefore implement the variable selection function. Our simulation studies suggest fast computation and superior performance of the proposed method. The developed algorithm has also been applied to real omics data.
590 $a School code: 0183.
650 4 $a Statistics. $3 517247
650 4 $a Biology, Bioinformatics. $3 1018415
690 $a 0463
690 $a 0715
710 2 $a Purdue University. $b Statistics. $3 1279962
773 0 $t Dissertation Abstracts International $g 74-04B(E).
790 1 0 $a Zhang, Dabao, $e advisor
790 1 0 $a Zhang, Min, $e advisor
790 1 0 $a Ghosh, Jayanta K. $e committee member
790 1 0 $a Muir, William M. $e committee member
790 $a 0183
791 $a Ph.D.
792 $a 2012
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3545358