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Light scattering properties vary acr...

Al-Juboori, Saif I.

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Light scattering properties vary across different regions of the adult mouse brain.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Light scattering properties vary across different regions of the adult mouse brain./
Author:	Al-Juboori, Saif I.
Description:	91 p.
Notes:	Source: Masters Abstracts International, Volume: 52-02.
Contained By:	Masters Abstracts International52-02(E).
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1544238
ISBN:	9781303337987

Light scattering properties vary across different regions of the adult mouse brain.
Al-Juboori, Saif I.

Light scattering properties vary across different regions of the adult mouse brain. - 91 p.

Source: Masters Abstracts International, Volume: 52-02.

Thesis (M.S.)--University of Colorado at Denver, 2013.

Recently developed optogenetic tools provide powerful approaches to optically excite or inhibit neural activity. In a typical in-vivo experiment, light is delivered to deep nuclei via an implanted optical fiber. Light intensity attenuates with increasing distance from the fiber tip, determining the volume of tissue in which optogenetic proteins can successfully be activated. However, whether and how this volume of effective light intensity varies as a function of brain region or wavelength has not been systematically studied.

ISBN: 9781303337987Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Light scattering properties vary across different regions of the adult mouse brain.
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020 $a 9781303337987
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100 1 $a Al-Juboori, Saif I. $3 2049762
245 1 0 $a Light scattering properties vary across different regions of the adult mouse brain.
300 $a 91 p.
500 $a Source: Masters Abstracts International, Volume: 52-02.
500 $a Adviser: Tim Lei.
502 $a Thesis (M.S.)--University of Colorado at Denver, 2013.
520 $a Recently developed optogenetic tools provide powerful approaches to optically excite or inhibit neural activity. In a typical in-vivo experiment, light is delivered to deep nuclei via an implanted optical fiber. Light intensity attenuates with increasing distance from the fiber tip, determining the volume of tissue in which optogenetic proteins can successfully be activated. However, whether and how this volume of effective light intensity varies as a function of brain region or wavelength has not been systematically studied.
520 $a The goal of this study was to measure and compare how light scatters in different areas of the mouse brain. We delivered different wavelengths of light via optical fibers to acute slices of mouse brainstem, midbrain and forebrain tissue. We measured light intensity as a function of distance from the fiber tip, and used the data to model the spread of light in specific regions of the mouse brain. We found substantial differences in effective attenuation coefficients among different brain areas, which lead to substantial differences in light intensity demands for optogenetic experiments. The use of light of different wavelengths additionally changes how light illuminates a given brain area. We created a brain atlas of effective attenuation coefficients of the adult mouse brain, and integrated our data into an application that can be used to estimate light scattering as well as required light intensity for optogenetic manipulation within a given volume of tissue.
590 $a School code: 0765.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Physics, Optics. $3 1018756
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0317
690 $a 0752
690 $a 0541
710 2 $a University of Colorado at Denver. $b Electrical Engineering. $3 2049763
773 0 $t Masters Abstracts International $g 52-02(E).
790 $a 0765
791 $a M.S.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1544238