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Occupational exposure to lead, genet...
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Rajaraman, Preetha.
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Occupational exposure to lead, genetic susceptibility and risk of adult brain tumors.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Occupational exposure to lead, genetic susceptibility and risk of adult brain tumors./
作者:
Rajaraman, Preetha.
面頁冊數:
179 p.
附註:
Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1817.
Contained By:
Dissertation Abstracts International65-04B.
標題:
Health Sciences, Public Health. -
電子資源:
http://wwwlib.umi.com/dissertations/fullcit/3130764
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3130764
Occupational exposure to lead, genetic susceptibility and risk of adult brain tumors.
Rajaraman, Preetha.
Occupational exposure to lead, genetic susceptibility and risk of adult brain tumors.
- 179 p.
Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1817.
Thesis (Ph.D.)--The Johns Hopkins University, 2004.
Introduction. Very little is known regarding the etiology of brain tumors. Prior studies indicate that exposure to lead may increase brain tumor risk. The K59N polymorphism of the gene coding for ∂-aminolevulinic acid dehydratase (ALAD) affects the toxicokinetics of lead in humans, and may modify the relationship between lead and brain tumor risk.Subjects--Topical Terms:
1017659
Health Sciences, Public Health.
Occupational exposure to lead, genetic susceptibility and risk of adult brain tumors.
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Occupational exposure to lead, genetic susceptibility and risk of adult brain tumors.
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Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1817.
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Thesis (Ph.D.)--The Johns Hopkins University, 2004.
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Introduction. Very little is known regarding the etiology of brain tumors. Prior studies indicate that exposure to lead may increase brain tumor risk. The K59N polymorphism of the gene coding for ∂-aminolevulinic acid dehydratase (ALAD) affects the toxicokinetics of lead in humans, and may modify the relationship between lead and brain tumor risk.
520
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Purpose. This research examines whether occupational exposure to lead increases the risk of the three most common brain tumor types (glioma, meningioma, and acoustic neuroma), and evaluates possible effect modification of the relationship between lead and brain tumor risk by ALAD K59N genotype.
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Methods. Study participants were 782 incident brain tumor cases (489 glioma, 197 meningioma, 96 acoustic neuroma) and 799 frequency-matched controls from the National Cancer Institute Adult Brain Tumor Study. Lifetime job history was collected by interview for all study participants. Jobs with similar tasks and exposures were grouped into occupational categories. Exposure to lead was assessed for each job, using data from a comprehensive literature review and consultation with an experienced industrial hygienist. Blood samples were collected and DNA extracted for 80% of subjects. ALAD K59N genotype was determined using a medium-to-high throughput Taqman assay.
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Results. Elevated risk of benign tumors was observed for the following occupations with possible exposure to lead: automotive body painters, designers and decorators, military occupations (meningioma), and gas station attendants (acoustic neuroma). Having ever had a job involving lead exposure was not significantly associated with overall risk of glioma, meningioma, or acoustic neuroma. However, risk of meningioma increased with number of years spent in lead-exposed jobs, and was significantly associated with working in such jobs for longer than 20 years. Overall, individuals with the ALAD2 allele had an increased risk of meningioma, but not glioma or acoustic neuroma. The association between lead exposure and meningioma was strongest for individuals carrying the ALAD2 variant of the K59N polymorphism.
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Conclusions. The results of this research, if replicated, may have important public health implications since lead is still widely used in both industrialized and developing countries. Stronger regulation of lead exposure, with a margin of safety for genetically susceptible groups, may be warranted.
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