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Anterior segment morphometry using o...

Wang, Jianhua.

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Anterior segment morphometry using optical coherence tomography.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Anterior segment morphometry using optical coherence tomography./
Author:	Wang, Jianhua.
Description:	196 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-08, Section: B, page: 3756.
Contained By:	Dissertation Abstracts International64-08B.
Subject:	Health Sciences, Ophthalmology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ83028
ISBN:	0612830284

Anterior segment morphometry using optical coherence tomography.
Wang, Jianhua.

Anterior segment morphometry using optical coherence tomography. - 196 p.

Source: Dissertation Abstracts International, Volume: 64-08, Section: B, page: 3756.

Thesis (Ph.D.)--University of Waterloo (Canada), 2003.

A series of experiments was designed to demonstrate the validity and utility of optical coherence tomography (OCT) for measuring the anterior segment, including topographical corneal thickness, tear film thickness and corneal transparency in living human eyes.

ISBN: 0612830284Subjects--Topical Terms:

1019445
Health Sciences, Ophthalmology.

Anterior segment morphometry using optical coherence tomography.
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020 $a 0612830284
035 $a (UnM)AAINQ83028
035 $a AAINQ83028
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100 1 $a Wang, Jianhua. $3 1684081
245 1 0 $a Anterior segment morphometry using optical coherence tomography.
300 $a 196 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-08, Section: B, page: 3756.
500 $a Advisers: Desmond Fonn; Trefford Simpson.
502 $a Thesis (Ph.D.)--University of Waterloo (Canada), 2003.
520 $a A series of experiments was designed to demonstrate the validity and utility of optical coherence tomography (OCT) for measuring the anterior segment, including topographical corneal thickness, tear film thickness and corneal transparency in living human eyes.
520 $a After 3 hours of wearing alignment soft and PMMA lenses, lens type, time and location were found to be significant main effects (p = 0.000) on corneal swelling in patched eyes using a 3-way ANOVA and there was a significant 3-way interaction among lens type, time and location of the cornea (F(df = 16, 272) = 1.78, p = 0.033). However, there was no significant main effect and interaction for epithelial thickness (F(df = 16, 222) = 0.33, p > 0.05).
520 $a After overnight wearing of flat-fitted reverse geometry design rigid gas permeable lenses (CRT(TM) lens), the cornea swelled and deswelled in a predictable fashion, with maximum swelling on eye opening and steady deswelling during the day (F(df = 6, 114) = 86.9; p = 0.000). Central corneal swelling differed between eyes (F(df = 1, 19) = 8.5; p = 0.009). Greater central swelling was induced by the control (alignment fitted) lens than the CRT(TM) lens (6.9 +/- 3.1 % vs. 4.9 +/- 2.0% respectively, post hoc: p = 0.002).
520 $a In the tear film study, the mean (+/- SD) pre-corneal tear film thickness was 3.3 +/- 1.5 mum (range: 0--6.9 mum) prior to lens insertion and 4.7 +/- 2.3 mum (range: 0.7--11.0 mum) after lens fitting, which was significantly thicker (paired t-test: p = 0.000). The pre-lens tear film thickness was 3.9 +/- 2.6 mum and 3.6 +/- 2.1 mum (Mean +/- SD) (paired t-test: p > 0.05) and the post-lens tear film thickness was 4.5 +/- 2.3 mum and 4.7 +/- 3.1 mum (paired t-test: p > 0.05) on and under Focus Night & Day(TM) and Acuvue(TM) lenses respectively.
520 $a Normalized backscattered light profiles which were plotted from OCT images of 20 subjects showed good repeatability of the baseline measurements. Immediately after 3 hours of HEMA contact lens wear and eye closure, total corneal thickness increased significantly by 13.8 +/- 2.3% (Mean +/- SD) compared to baseline (p = 0.000, paired t-test) then decreased during deswelling course.
520 $a OCT is a valid tool for measurements of topographical corneal and epithelial thickness and tear film thickness. It also provides an objective estimation of corneal backscattered light. The study with on-K fitting soft and PMMA lenses shows corneal swelling is dependent on lens type and corneal location but epithelial thickness across the horizontal corneal meridian does not change after lens wear and eye closure. The study with reverse geometry design rigid gas permeable lenses shows central epithelial thinning and redistribution of corneal thickness may be responsible for the alteration of refraction changes after overnight CRT(TM) lens wear. The tear film study demonstrates that the thickness of the normal pre-corneal tear film is about 3 mum and becomes thicker after lens fitting. The post-lens tear film is thicker than the pre-corneal and pre-lens tear films with soft contact lenses. The thickness of both pre- and post-lens tear films appears to be independent of lens types tested in this study. Furthermore, corneal backscatter increases in the epithelium and posterior stroma during corneal swelling induced by contact lens wear and eye closure. (Abstract shortened by UMI.)
590 $a School code: 1141.
650 4 $a Health Sciences, Ophthalmology. $3 1019445
650 4 $a Biology, Animal Physiology. $3 1017835
690 $a 0381
690 $a 0433
710 2 0 $a University of Waterloo (Canada). $3 1017669
773 0 $t Dissertation Abstracts International $g 64-08B.
790 1 0 $a Fonn, Desmond, $e advisor
790 1 0 $a Simpson, Trefford, $e advisor
790 $a 1141
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ83028