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Modulation of spinal morphine analge...

Abul-Husn, Noura Serene.

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Modulation of spinal morphine analgesia and tolerance by ultra-low doses of competitive and functional opioid receptor antagonists.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Modulation of spinal morphine analgesia and tolerance by ultra-low doses of competitive and functional opioid receptor antagonists./
作者:	Abul-Husn, Noura Serene.
面頁冊數:	99 p.
附註:	Source: Masters Abstracts International, Volume: 41-01, page: 0204.
Contained By:	Masters Abstracts International41-01.
標題:	Health Sciences, Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ69341
ISBN:	0612693414

Modulation of spinal morphine analgesia and tolerance by ultra-low doses of competitive and functional opioid receptor antagonists.
Abul-Husn, Noura Serene.

Modulation of spinal morphine analgesia and tolerance by ultra-low doses of competitive and functional opioid receptor antagonists. - 99 p.

Source: Masters Abstracts International, Volume: 41-01, page: 0204.

Thesis (M.Sc.)--Queen's University at Kingston (Canada), 2002.

Opioids traditionally produce an inhibitory effect on neuronal activity, resulting in analgesia. However, there is mounting evidence that, at extremely low doses, opioid agonists such as morphine exert excitatory effects, which can be selectively blocked by ultra-low doses of opioid receptor antagonists such as naltrexone (NTX). The excitatory actions of morphine are thought to compromise analgesia and contribute to the genesis of morphine tolerance and physical dependence. Previous studies in this laboratory have shown that ultra-low doses of NTX inhibit the development and expression of morphine tolerance. Since NTX can act at both mu and delta receptors, the present study determined the specificity of this action by using the selective mu and delta receptor antagonists, CTOP and naltrindole (NTI). The effects of a functional opioid antagonist, the adenosine A1 receptor antagonist 8-phenyltheophylline (8-PT), on morphine action were also examined.

ISBN: 0612693414Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Modulation of spinal morphine analgesia and tolerance by ultra-low doses of competitive and functional opioid receptor antagonists.
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245 1 0 $a Modulation of spinal morphine analgesia and tolerance by ultra-low doses of competitive and functional opioid receptor antagonists.
300 $a 99 p.
500 $a Source: Masters Abstracts International, Volume: 41-01, page: 0204.
500 $a Adviser: Khem Jhamandas.
502 $a Thesis (M.Sc.)--Queen's University at Kingston (Canada), 2002.
520 $a Opioids traditionally produce an inhibitory effect on neuronal activity, resulting in analgesia. However, there is mounting evidence that, at extremely low doses, opioid agonists such as morphine exert excitatory effects, which can be selectively blocked by ultra-low doses of opioid receptor antagonists such as naltrexone (NTX). The excitatory actions of morphine are thought to compromise analgesia and contribute to the genesis of morphine tolerance and physical dependence. Previous studies in this laboratory have shown that ultra-low doses of NTX inhibit the development and expression of morphine tolerance. Since NTX can act at both mu and delta receptors, the present study determined the specificity of this action by using the selective mu and delta receptor antagonists, CTOP and naltrindole (NTI). The effects of a functional opioid antagonist, the adenosine A1 receptor antagonist 8-phenyltheophylline (8-PT), on morphine action were also examined.
520 $a This study reveals that ultra-low doses of mu and delta receptor antagonists modulate morphine antinociception and tolerance through a spinal action. It is also possible to enhance morphine antinociception using ultra-low doses of an adenosine A1 receptor antagonist. (Abstract shortened by UMI.)
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