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NF-kappa B and the regulation of Sin...

Lin, Kuo-I.

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NF-kappa B and the regulation of Sindbis virus-induced apoptosis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	NF-kappa B and the regulation of Sindbis virus-induced apoptosis./
Author:	Lin, Kuo-I.
Description:	193 p.
Notes:	Source: Dissertation Abstracts International, Volume: 59-05, Section: B, page: 1965.
Contained By:	Dissertation Abstracts International59-05B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9832928
ISBN:	0591860775

NF-kappa B and the regulation of Sindbis virus-induced apoptosis.
Lin, Kuo-I.

NF-kappa B and the regulation of Sindbis virus-induced apoptosis. - 193 p.

Source: Dissertation Abstracts International, Volume: 59-05, Section: B, page: 1965.

Thesis (Ph.D.)--The Johns Hopkins University, 1998.

Apoptosis, known as programmed cell death, is an active, genetically-controlled process utilized by multicellular organisms to eliminate unwanted or unhealthy cells during development and throughout adulthood. Sindbis virus (SV), an alphavirus, can induce apoptosis in cultured cell lines and in neurons of mice, however, the signaling pathway(s) by which SV triggers apoptosis is still unclear. It has been proposed that oxidative stress is a common mediator for inducing apoptosis. To investigate whether the SV-induced apoptotic pathway results from generation of free radical species, we assessed the effects of antioxidants on SV-induced cell death. We found that several antioxidants failed to protect from SV-induced apoptosis, suggesting that free radical species are not required for initiating SV-induced apoptosis. However, thiol agents, such as N-acetylcysteine were able to protect from SV-induced apoptosis, and the protective effects of thiol agents could be correlated with their abilities to suppress SV-induced transcription factor NF-

ISBN: 0591860775Subjects--Topical Terms:

1017686
Biology, Cell.

NF-kappa B and the regulation of Sindbis virus-induced apoptosis.
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035 $a (UnM)AAI9832928
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100 1 $a Lin, Kuo-I. $3 1952583
245 1 0 $a NF-kappa B and the regulation of Sindbis virus-induced apoptosis.
300 $a 193 p.
500 $a Source: Dissertation Abstracts International, Volume: 59-05, Section: B, page: 1965.
500 $a Advisers: J. Marie Hardwick; Diane E. Griffin.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 1998.
520 $a Apoptosis, known as programmed cell death, is an active, genetically-controlled process utilized by multicellular organisms to eliminate unwanted or unhealthy cells during development and throughout adulthood. Sindbis virus (SV), an alphavirus, can induce apoptosis in cultured cell lines and in neurons of mice, however, the signaling pathway(s) by which SV triggers apoptosis is still unclear. It has been proposed that oxidative stress is a common mediator for inducing apoptosis. To investigate whether the SV-induced apoptotic pathway results from generation of free radical species, we assessed the effects of antioxidants on SV-induced cell death. We found that several antioxidants failed to protect from SV-induced apoptosis, suggesting that free radical species are not required for initiating SV-induced apoptosis. However, thiol agents, such as N-acetylcysteine were able to protect from SV-induced apoptosis, and the protective effects of thiol agents could be correlated with their abilities to suppress SV-induced transcription factor NF- $\ kappa $\ kappa $\ kappa $\ kappa $\ kappa $\ kappa $\ kappa $\ kappa $\ kappa $\ kappa $\ alpha $ (I $\ kappa $\ kappa $\ kappa $\ kappa $\ kappa $\ kappa
590 $a School code: 0098.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Molecular. $3 1017719
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710 2 0 $a The Johns Hopkins University. $3 1017431
773 0 $t Dissertation Abstracts International $g 59-05B.
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790 1 0 $a Griffin, Diane E., $e advisor
790 $a 0098
791 $a Ph.D.
792 $a 1998
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