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Gene-environment interaction in asth...

Zambelli-Weiner, April.

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Gene-environment interaction in asthma: CD14 and endotoxin.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Gene-environment interaction in asthma: CD14 and endotoxin./
Author:	Zambelli-Weiner, April.
Description:	163 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-10, Section: B, page: 4751.
Contained By:	Dissertation Abstracts International64-10B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3107585

Gene-environment interaction in asthma: CD14 and endotoxin.
Zambelli-Weiner, April.

Gene-environment interaction in asthma: CD14 and endotoxin. - 163 p.

Source: Dissertation Abstracts International, Volume: 64-10, Section: B, page: 4751.

Thesis (Ph.D.)--The Johns Hopkins University, 2004.

Asthma is a complex disease of the lower airways in which the interplay between genetic factors and environmental exposures has significant influence on both susceptibility and disease prognosis. Given what we know about the multifactorial etiology of asthma and the limitations of traditional linkage approaches, candidate gene studies provide a better opportunity for identification of asthma-regulating genes, as well as measurement of the joint effects of genetic and environmental risk factors. Endotoxin is a cellular wall component of gram-negative bacteria with potent pro-inflammatory capabilities. Endotoxin has been shown to be active in domestic house dust extracts and to be associated with markers of asthma severity. As part of the ongoing Barbados Asthma Genetics Study (BAGS), this study proposes a family-based design to assess the interactive effect of domestic endotoxin exposure and a functional polymorphism in a key candidate gene for asthma, CD14, on measures of asthma severity. The specific aims of this study are: (1) To determine if the CD14(C-159T) variant is independently associated with asthma outcomes including biological markers (total IgE), physical measures (lung function testing), and a non-objective index of severity (severity questionnaire); (2) To describe endotoxin levels in a tropical environment and to test for association between house dust endotoxin exposure and asthma severity; (3) To test combinations of the above genetic and environmental risk factors for putative gene-environment interactions based on their posited role in asthma pathogenesis. The analysis will be conducted utilizing the family-based association test (FBAT) and traditional linear regression models. Designed specifically for family-based data, FBAT tests for both association and linkage and, unlike the traditional case-control approach, is impervious to the confounding effects of population stratification. The characterization of gene-by-environment interactions that modulate the course of asthma will have an important impact on the development of novel interventions and therapies.Subjects--Topical Terms:

1017730
Biology, Genetics.

Gene-environment interaction in asthma: CD14 and endotoxin.
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520 $a Asthma is a complex disease of the lower airways in which the interplay between genetic factors and environmental exposures has significant influence on both susceptibility and disease prognosis. Given what we know about the multifactorial etiology of asthma and the limitations of traditional linkage approaches, candidate gene studies provide a better opportunity for identification of asthma-regulating genes, as well as measurement of the joint effects of genetic and environmental risk factors. Endotoxin is a cellular wall component of gram-negative bacteria with potent pro-inflammatory capabilities. Endotoxin has been shown to be active in domestic house dust extracts and to be associated with markers of asthma severity. As part of the ongoing Barbados Asthma Genetics Study (BAGS), this study proposes a family-based design to assess the interactive effect of domestic endotoxin exposure and a functional polymorphism in a key candidate gene for asthma, CD14, on measures of asthma severity. The specific aims of this study are: (1) To determine if the CD14(C-159T) variant is independently associated with asthma outcomes including biological markers (total IgE), physical measures (lung function testing), and a non-objective index of severity (severity questionnaire); (2) To describe endotoxin levels in a tropical environment and to test for association between house dust endotoxin exposure and asthma severity; (3) To test combinations of the above genetic and environmental risk factors for putative gene-environment interactions based on their posited role in asthma pathogenesis. The analysis will be conducted utilizing the family-based association test (FBAT) and traditional linear regression models. Designed specifically for family-based data, FBAT tests for both association and linkage and, unlike the traditional case-control approach, is impervious to the confounding effects of population stratification. The characterization of gene-by-environment interactions that modulate the course of asthma will have an important impact on the development of novel interventions and therapies.
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