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Synthesis and characterization of fu...

Warner, Marvin Glen.

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Synthesis and characterization of functionalized gold nanoparticles and their rational arrangement on DNA scaffolds.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Synthesis and characterization of functionalized gold nanoparticles and their rational arrangement on DNA scaffolds./
作者:	Warner, Marvin Glen.
面頁冊數:	204 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2694.
Contained By:	Dissertation Abstracts International64-06B.
標題:	Chemistry, Physical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3095284

Synthesis and characterization of functionalized gold nanoparticles and their rational arrangement on DNA scaffolds.
Warner, Marvin Glen.

Synthesis and characterization of functionalized gold nanoparticles and their rational arrangement on DNA scaffolds. - 204 p.

Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2694.

Thesis (Ph.D.)--University of Oregon, 2003.

Functionalized metal nanoparticles have received an enormous amount of attention for their use as catalysts/catalyst supports, biological taggants, sensors, and as building blocks of nanoelectronic devices. In order for these materials to be useful in any of the above applications, a method for synthesizing the nanoparticles and reliably patterning and interconnecting them is necessary. Presented here is a method for the synthesis and characterization of functionalized gold nanoparticles that are shown to form extended, well-ordered, low-dimensional assemblies along a DNA template. These types of assemblies will undoubtedly prove highly useful in the fabrication of nanoparticle-based devices.Subjects--Topical Terms:

560527
Chemistry, Physical.

Synthesis and characterization of functionalized gold nanoparticles and their rational arrangement on DNA scaffolds.
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100 1 $a Warner, Marvin Glen. $3 1952120
245 1 0 $a Synthesis and characterization of functionalized gold nanoparticles and their rational arrangement on DNA scaffolds.
300 $a 204 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2694.
500 $a Adviser: James E. Hutchison.
502 $a Thesis (Ph.D.)--University of Oregon, 2003.
520 $a Functionalized metal nanoparticles have received an enormous amount of attention for their use as catalysts/catalyst supports, biological taggants, sensors, and as building blocks of nanoelectronic devices. In order for these materials to be useful in any of the above applications, a method for synthesizing the nanoparticles and reliably patterning and interconnecting them is necessary. Presented here is a method for the synthesis and characterization of functionalized gold nanoparticles that are shown to form extended, well-ordered, low-dimensional assemblies along a DNA template. These types of assemblies will undoubtedly prove highly useful in the fabrication of nanoparticle-based devices.
520 $a The synthetic procedure presented herein begins with the synthesis of a common precursor particle, Au101(PPh3)21Cl 5. This particle is analogous to the phosphine-stabilized particles first synthesized by Schmid (originally formulated as Au55(PPh 3)12Cl6) in its small size (dcore < 2 nm) and narrow size dispersity (&sim;30%) as well as its ability to undergo ligand exchange with functionalized thiols. Our synthesis of this new precursor eliminates the harsh reagents (e.g. diborane gas) used in the traditional procedure and provides a scalable reaction capable of producing gram quantities of the purified nanoparticle product.
520 $a This phosphine-stabilized precursor nanoparticle can be functionalized using a biphasic ligand exchange reaction to yield thiol-stabilized nanoparticles that are capable of interacting with a DNA structural template. Specifically, thiocholine (N,N,N-trimethylaminoethanethiol iodide) is used to both impart water-solubility to the nanoparticle (a necessary requirement for biopolymer templating) and to provide a terminal ammonium headgroup in the stabilizing ligand shell that is capable of electrostatically binding to the negatively charged phosphate backbone of DNA.
520 $a The structures formed using these nanoparticles and lambda-DNA ( Hind III enzyme digest) provide some of the first examples of well-ordered, extended, low-dimensional nanoparticle assemblies in which the nanoparticles are observed to be close-packed along the DNA strand. Further, this is one of the first examples in which the individual nanoparticles attached to the DNA template were clearly visualized using transmission electron microscopy allowing for more in depth characterization of the assemblies and a higher level of control over the assembly process.
520 $a This dissertation includes both previously published and unpublished co-authored material.
590 $a School code: 0171.
650 4 $a Chemistry, Physical. $3 560527
650 4 $a Chemistry, Inorganic. $3 517253
690 $a 0494
690 $a 0488
710 2 0 $a University of Oregon. $3 958250
773 0 $t Dissertation Abstracts International $g 64-06B.
790 1 0 $a Hutchison, James E., $e advisor
790 $a 0171
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3095284