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Cell cycle regulation of yeast morph...

Tobe, Brian T. D.

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Cell cycle regulation of yeast morphogenesis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Cell cycle regulation of yeast morphogenesis./
Author:	Tobe, Brian T. D.
Description:	200 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5942.
Contained By:	Dissertation Abstracts International64-12B.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3116992

Cell cycle regulation of yeast morphogenesis.
Tobe, Brian T. D.

Cell cycle regulation of yeast morphogenesis. - 200 p.

Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5942.

Thesis (Ph.D.)--The University of Chicago, 2004.

Cell division is a highly regulated process in eukaryotic organisms including multicellular plants and animals and unicellular microbes. Of these diverse species, the unicellular yeast S. cerevisiae is the most well suited for genetic analyses. Subjects--Topical Terms:

1017719
Biology, Molecular.

Cell cycle regulation of yeast morphogenesis.
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100 1 $a Tobe, Brian T. D. $3 1950182
245 1 0 $a Cell cycle regulation of yeast morphogenesis.
300 $a 200 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5942.
500 $a Adviser: Stephen J. Kron.
502 $a Thesis (Ph.D.)--The University of Chicago, 2004.
520 $a Cell division is a highly regulated process in eukaryotic organisms including multicellular plants and animals and unicellular microbes. Of these diverse species, the unicellular yeast S. cerevisiae is the most well suited for genetic analyses.
520 $a The yeast cell cycle, as in other eukaryotes, is controlled by cyclin dependent kinase (CDK). CDC28 is the major yeast CDK that modulates each cell cycle transition by phosphorylation of protein substrates. In turn, CDK is positively and negativ
520 $a Although yeast normally persist as circular cells forming round colonies, delay in the onset of chromosome separation (mitosis), leads to cellular elongation. Propagation of polarized cells produces a filamentous colony appearance in which pseud
520 $a We hypothesized that the cell cycle machinery may be a target in signaling of filamentous growth. Toward understanding these mechanisms, we identified cdc28 alleles that exhibit constitutive filamentation. The mutations localized throughout the
520 $a A large number of the substitutions also altered the binding site of Cks1, a highly conserved, essential CDK subunit, suggesting a role for Cks1 in morphogenesis. The phenotypes of one mutant, cdc28-E217V, that diminished Cks1 association, depen
590 $a School code: 0330.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Cell. $3 1017686
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690 $a 0369
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710 2 0 $a The University of Chicago. $3 1017389
773 0 $t Dissertation Abstracts International $g 64-12B.
790 1 0 $a Kron, Stephen J., $e advisor
790 $a 0330
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3116992