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Towards an understanding of zebrafis...

McFarland, Karen Noelle.

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Towards an understanding of zebrafish epiboly: Characterization and molecular identification of the epiboly mutant half baked.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Towards an understanding of zebrafish epiboly: Characterization and molecular identification of the epiboly mutant half baked./
Author:	McFarland, Karen Noelle.
Description:	314 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5887.
Contained By:	Dissertation Abstracts International64-12B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3114915

Towards an understanding of zebrafish epiboly: Characterization and molecular identification of the epiboly mutant half baked.
McFarland, Karen Noelle.

Towards an understanding of zebrafish epiboly: Characterization and molecular identification of the epiboly mutant half baked. - 314 p.

Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5887.

Thesis (Ph.D.)--The University of Rochester, 2004.

The zebrafish mutation half baked (hab) blocks epiboly, the vegetalwards movement of the deep cells around the giant yolk cell. In these embryos, only epiboly of the deep cells is affected, the enveloping layer cells and the yolk syncytial layerSubjects--Topical Terms:

1017686
Biology, Cell.

Towards an understanding of zebrafish epiboly: Characterization and molecular identification of the epiboly mutant half baked.
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035 $a AAI3114915
040 $a UnM $c UnM
100 1 $a McFarland, Karen Noelle. $3 1950162
245 1 0 $a Towards an understanding of zebrafish epiboly: Characterization and molecular identification of the epiboly mutant half baked.
300 $a 314 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5887.
500 $a Supervisor: Donald A. Kane.
502 $a Thesis (Ph.D.)--The University of Rochester, 2004.
520 $a The zebrafish mutation half baked (hab) blocks epiboly, the vegetalwards movement of the deep cells around the giant yolk cell. In these embryos, only epiboly of the deep cells is affected, the enveloping layer cells and the yolk syncytial layer
520 $a The second chapter of this thesis describes a characterization study on hab which revealed that hab does affect general specification or differentiation of tissues. Involution, the internalization of presumptive mesendodermal cells, was also not
520 $a In the third chapter, I present extensive genetic mapping data that localizes hab to the vicinity of the centromere on linkage group 7. Additionally, double recombination events, thought to be rare occurrences, were observed on each arm of the
520 $a The gene product produced by the hab locus was identified as E-cadherin. E-cadherin expression was then examined in wild-type and mutant embryos with correlations observed between sites of expression and hab defects. Using the multiple missense
520 $a At the end of this thesis, I present models for how E-cadherin may function during the morphogenetic movements of epiboly and convergence.
590 $a School code: 0188.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
690 $a 0379
690 $a 0369
690 $a 0307
710 2 0 $a The University of Rochester. $3 1249304
773 0 $t Dissertation Abstracts International $g 64-12B.
790 1 0 $a Kane, Donald A., $e advisor
790 $a 0188
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3114915