東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

The evolution of antibiotic resistance.

Barlow, Miriam.

FindBook

Google Book

Amazon

博客來

The evolution of antibiotic resistance.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The evolution of antibiotic resistance./
作者:	Barlow, Miriam.
面頁冊數:	149 p.
附註:	Source: Dissertation Abstracts International, Volume: 63-12, Section: B, page: 5660.
Contained By:	Dissertation Abstracts International63-12B.
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3074517
ISBN:	0493945490

The evolution of antibiotic resistance.
Barlow, Miriam.

The evolution of antibiotic resistance. - 149 p.

Source: Dissertation Abstracts International, Volume: 63-12, Section: B, page: 5660.

Thesis (Ph.D.)--The University of Rochester, 2003.

The evolution of antibiotic resistance is becoming an enormous threat to human health while at the same time providing an unparalleled opportunity to study evolutionary processes as they occur. The beta-lactamases are one of the largest and most extensively studied groups of antibiotic resistance genes. The TEM, ampC, and OXA resistance genes are examples of three beta-lactamases that have become widespread and that confer resistance to the beta-lactam antibiotics upon many different species of bacteria. While it is widely believed that antibiotic resistance has evolved as a direct consequence of the modern use of antibiotics, very little research actually supports this belief.

ISBN: 0493945490Subjects--Topical Terms:

1017734
Biology, Microbiology.

The evolution of antibiotic resistance.
LDR:02999nmm 2200325 4500 001 1861835
005 20041215074112.5
008 130614s2003 eng d
020 $a 0493945490
035 $a (UnM)AAI3074517
035 $a AAI3074517
040 $a UnM $c UnM
100 1 $a Barlow, Miriam. $3 1949415
245 1 4 $a The evolution of antibiotic resistance.
300 $a 149 p.
500 $a Source: Dissertation Abstracts International, Volume: 63-12, Section: B, page: 5660.
500 $a Supervisor: Barry G. Hall.
502 $a Thesis (Ph.D.)--The University of Rochester, 2003.
520 $a The evolution of antibiotic resistance is becoming an enormous threat to human health while at the same time providing an unparalleled opportunity to study evolutionary processes as they occur. The beta-lactamases are one of the largest and most extensively studied groups of antibiotic resistance genes. The TEM, ampC, and OXA resistance genes are examples of three beta-lactamases that have become widespread and that confer resistance to the beta-lactam antibiotics upon many different species of bacteria. While it is widely believed that antibiotic resistance has evolved as a direct consequence of the modern use of antibiotics, very little research actually supports this belief.
520 $a Through phenotypic characterization of two ampC alleles taken from two antibiotic strains of Citrobacter freundii that were collected prior to the clinical introduction of antibiotics, we have shown that the ampC gene was capable of conferring resistance to beta-lactams before antibiotics came into clinical use.
520 $a Through phylogenetic analysis, we have shown that the OXA beta-lactamases were mobilized to plasmids millions of years ago. This result means that not all resistance genes have been mobilized to plasmids in response to the clinical use of antibiotics.
520 $a Finally, we have developed an in vitro evolution method for predicting how antibiotic resistance genes will evolve in the future. By reproducing the evolution of the TEM beta-lactamases that has occurred during the past 20 years, we demonstrated that the in vitro evolution method, when properly applied, can cause genes to evolve in the lab the same way that they evolve in nature. Because mutations can be introduced at a much higher frequency in the lab than in nature, it is possible to accelerate evolutionary processes and predict how genes will evolve in nature.
520 $a We have used this method to show that the TEM and AmpC beta-lactamases found in nature will probably evolve the ability to confer resistance to the beta-lactam antibiotic cefepime, and to predict the amino acid substitutions that will result in that evolution.
590 $a School code: 0188.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Genetics. $3 1017730
690 $a 0410
690 $a 0369
710 2 0 $a The University of Rochester. $3 1249304
773 0 $t Dissertation Abstracts International $g 63-12B.
790 1 0 $a Hall, Barry G., $e advisor
790 $a 0188
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3074517