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Chromatographic studies of drug-prot...

Chen, Jianzhong.

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Chromatographic studies of drug-protein interactions.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Chromatographic studies of drug-protein interactions./
作者:	Chen, Jianzhong.
面頁冊數:	208 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 6057.
Contained By:	Dissertation Abstracts International64-12B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3116565

Chromatographic studies of drug-protein interactions.
Chen, Jianzhong.

Chromatographic studies of drug-protein interactions. - 208 p.

Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 6057.

Thesis (Ph.D.)--The University of Nebraska - Lincoln, 2003.

High-performance affinity chromatography (HPAC) was used to study various drug-protein interactions. The binding studies of phenytoin to human serum albumin (HSA) was first investigated by zonal elution using four probes for specific sites on HSA. It was found that phenytoin had interactions with major and minor sites on HSA, with the interactions between two probes, (i.e. R-warfarin and cis-clomiphene) with phenytoin showing a complicated phenomenon involving both allosteric and competitive interactions. A theory was proposed to study allosteric interactions by HPAC and was used to analyze the data in two previous papers plus new experiments including phenytoin-L-tryptophan interactions. The results was consistent with those obtained by other methods.Subjects--Topical Terms:

586156
Chemistry, Analytical.

Chromatographic studies of drug-protein interactions.
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500 $a Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 6057.
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502 $a Thesis (Ph.D.)--The University of Nebraska - Lincoln, 2003.
520 $a High-performance affinity chromatography (HPAC) was used to study various drug-protein interactions. The binding studies of phenytoin to human serum albumin (HSA) was first investigated by zonal elution using four probes for specific sites on HSA. It was found that phenytoin had interactions with major and minor sites on HSA, with the interactions between two probes, (i.e. R-warfarin and cis-clomiphene) with phenytoin showing a complicated phenomenon involving both allosteric and competitive interactions. A theory was proposed to study allosteric interactions by HPAC and was used to analyze the data in two previous papers plus new experiments including phenytoin-L-tryptophan interactions. The results was consistent with those obtained by other methods.
520 $a Due to the low solubility of some drugs, to increase their solubility without affecting protein binding, beta-cyclodextrin was used as a mobile phase additive. A theory to obtain binding constants for drugs with beta-cyclodextrin by HPAC was proposed. Warfarin, tamoxifen and phenytoin binding were studied by this approach. The binding constants for beta-cyclodextrin with these drugs were then used to study the allosteric interactions of nonpolar drugs. A theory for studying these allosteric interactions was developed to include the use of beta-cyclodextrin as a mobile phase additive. This theory was then used to study warfarin-tamoxifen interactions.
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