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Lactobacillus acidophilus NCFMRTM: ...

Varcoe, Jeffrey John.

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Lactobacillus acidophilus NCFMRTM: An evaluation of its probiotic properties.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Lactobacillus acidophilus NCFMRTM: An evaluation of its probiotic properties./
Author:	Varcoe, Jeffrey John.
Description:	102 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1566.
Contained By:	Dissertation Abstracts International64-04B.
Subject:	Agriculture, Food Science and Technology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3087795

Lactobacillus acidophilus NCFMRTM: An evaluation of its probiotic properties.
Varcoe, Jeffrey John.

Lactobacillus acidophilus NCFMRTM: An evaluation of its probiotic properties. - 102 p.

Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1566.

Thesis (Ph.D.)--University of Minnesota, 2003.

Lactobacillus acidophilus has been thoroughly investigated as a human probiotic; however, there is little evidence to support the notion that L. acidophilus, specifically L. acidophilus NCFMRTM, will prevent bacterial gastroenteritis. Even though L. acidophilus NCFMRTM has been thoroughly studied, it is not known if L. acidophilus NCFM RTM can transit the gastrointestinal tract successfully or if can prevent illness caused by an enteric pathogen. The objectives of this thesis were to determine if: (1) the delivery vehicles for Lactobacillus acidophilus NCFMRTM would influence the human fecal microbiota; (2) Lactobacillus acidophilus NCFM RTM would protect mice from developing transmissible murine colonic hyperplasia (TMCH) caused by Citrobacter rodentium; and (3) C. rodentium had virulence genes in common with the human foodborne pathogens enterohemorrhagic Escherichia coli O157:H7 (EHEC) and E. coli O39:NM.Subjects--Topical Terms:

1017813
Agriculture, Food Science and Technology.

Lactobacillus acidophilus NCFMRTM: An evaluation of its probiotic properties.
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035 $a (UnM)AAI3087795
035 $a AAI3087795
040 $a UnM $c UnM
100 1 $a Varcoe, Jeffrey John. $3 1948950
245 1 0 $a Lactobacillus acidophilus NCFMRTM: An evaluation of its probiotic properties.
300 $a 102 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1566.
500 $a Advisers: Linda J. Brady; Francis F. Busta.
502 $a Thesis (Ph.D.)--University of Minnesota, 2003.
520 $a Lactobacillus acidophilus has been thoroughly investigated as a human probiotic; however, there is little evidence to support the notion that L. acidophilus, specifically L. acidophilus NCFMRTM, will prevent bacterial gastroenteritis. Even though L. acidophilus NCFMRTM has been thoroughly studied, it is not known if L. acidophilus NCFM RTM can transit the gastrointestinal tract successfully or if can prevent illness caused by an enteric pathogen. The objectives of this thesis were to determine if: (1) the delivery vehicles for Lactobacillus acidophilus NCFMRTM would influence the human fecal microbiota; (2) Lactobacillus acidophilus NCFM RTM would protect mice from developing transmissible murine colonic hyperplasia (TMCH) caused by Citrobacter rodentium; and (3) C. rodentium had virulence genes in common with the human foodborne pathogens enterohemorrhagic Escherichia coli O157:H7 (EHEC) and E. coli O39:NM.
520 $a There was no apparent collective advantage to using milk versus water as a delivery vehicle for L. acidophilus NCFMRTM . In addition, continuous feeding of L. acidophilus was required to maintain elevated lactobacilli populations in human subjects. Even though the lactobacilli population did increase while human subjects consumed the probiotic, the exogenous L. acidophilus NCFM RTM did not affect the populations other endogenous genera of bacteria.
520 $a A mouse model using C. rodentium as a surrogate for EHEC was developed and used to investigate the ability of L. acidophilus NCFMRTM to prevent gastrointestinal disease. It was determined that L. acidophilus NCFMRTM did attenuate overt colonic hyperplasia when fed to mice prior to being challenged with C. rodentium. No protective effect was observed when the probiotic was fed to mice at the same time that the pathogen was orally administered.
520 $a Furthermore, it was discovered that C. rodentium, EHEC, and E. coli O39:NM are more similar than previously known, these organisms possess multiple virulence genes that are quite similar further validating the use of C. rodentium as a valid model for future probiotic research.
520 $a These data indicate that L. acidophilus NCFM RTM is efficacious at preventing gastrointestinal illness caused by bacterial pathogens. It appears that it is the frequency of consumption of the probiotic that may influence the efficacy of the probiotic versus the type of delivery vehicle used.
590 $a School code: 0130.
650 4 $a Agriculture, Food Science and Technology. $3 1017813
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0359
690 $a 0410
690 $a 0570
710 2 0 $a University of Minnesota. $3 676231
773 0 $t Dissertation Abstracts International $g 64-04B.
790 1 0 $a Brady, Linda J., $e advisor
790 1 0 $a Busta, Francis F., $e advisor
790 $a 0130
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3087795