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The role of SepB in the maintenance ...

Gygax, Scott Elliott.

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The role of SepB in the maintenance of genome stability in Aspergillus nidulans.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The role of SepB in the maintenance of genome stability in Aspergillus nidulans./
Author:	Gygax, Scott Elliott.
Description:	120 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5929.
Contained By:	Dissertation Abstracts International64-12B.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3116828

The role of SepB in the maintenance of genome stability in Aspergillus nidulans.
Gygax, Scott Elliott.

The role of SepB in the maintenance of genome stability in Aspergillus nidulans. - 120 p.

Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5929.

Thesis (Ph.D.)--The University of Connecticut, 2003.

SepB is an essential protein required for chromosomal DNA metabolism in Aspergillus nidulans. SepB is a member of a conserved family of proteins that includes homologs in yeast (Ctf4p) and humans (hAND-1). A characteristic feature of these proteins is the presence of multiple protein-protein interaction domains, which suggests that they may function as molecular scaffolds. We provide evidence that SepB functions in the repair of DNA double strand breaks (DSBs) via the homologous recombination pathway, as demonstrated by the genetic interactions with uvsC (RAD51), musN (RECQ/BLM), and uvsB (ATR) and the sepB3 sensitivity to agents that cause DSBs. We also provide evidence that the loss of SepB function disrupts the formation of DNA damage induced UvsC (RAD51) nuclear foci, the proposed site of active DNA repair. We propose that SepB/AND-1 protein family members facilitate the formation of a multimeric protein complex that functions in DNA replication and homologous recombination. Moreover, our results suggest that SepB/AND-1 dysfunction can genetically modify the mutant phenotypes caused by mutations affecting RecQ/BLM or Mec1p/ATR.Subjects--Topical Terms:

1017719
Biology, Molecular.

The role of SepB in the maintenance of genome stability in Aspergillus nidulans.
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035 $a (UnM)AAI3116828
035 $a AAI3116828
040 $a UnM $c UnM
100 1 $a Gygax, Scott Elliott. $3 1948678
245 1 4 $a The role of SepB in the maintenance of genome stability in Aspergillus nidulans.
300 $a 120 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-12, Section: B, page: 5929.
500 $a Adviser: Steven Harris.
502 $a Thesis (Ph.D.)--The University of Connecticut, 2003.
520 $a SepB is an essential protein required for chromosomal DNA metabolism in Aspergillus nidulans. SepB is a member of a conserved family of proteins that includes homologs in yeast (Ctf4p) and humans (hAND-1). A characteristic feature of these proteins is the presence of multiple protein-protein interaction domains, which suggests that they may function as molecular scaffolds. We provide evidence that SepB functions in the repair of DNA double strand breaks (DSBs) via the homologous recombination pathway, as demonstrated by the genetic interactions with uvsC (RAD51), musN (RECQ/BLM), and uvsB (ATR) and the sepB3 sensitivity to agents that cause DSBs. We also provide evidence that the loss of SepB function disrupts the formation of DNA damage induced UvsC (RAD51) nuclear foci, the proposed site of active DNA repair. We propose that SepB/AND-1 protein family members facilitate the formation of a multimeric protein complex that functions in DNA replication and homologous recombination. Moreover, our results suggest that SepB/AND-1 dysfunction can genetically modify the mutant phenotypes caused by mutations affecting RecQ/BLM or Mec1p/ATR.
590 $a School code: 0056.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0307
690 $a 0369
690 $a 0410
710 2 0 $a The University of Connecticut. $3 1249323
773 0 $t Dissertation Abstracts International $g 64-12B.
790 1 0 $a Harris, Steven, $e advisor
790 $a 0056
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3116828