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Genome-scale characterization of nor...

Alizadeh, Arash Ash.

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Genome-scale characterization of normal and pathological gene expression programs in immune cells.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Genome-scale characterization of normal and pathological gene expression programs in immune cells./
Author:	Alizadeh, Arash Ash.
Description:	203 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2005.
Contained By:	Dissertation Abstracts International64-05B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3090550

Genome-scale characterization of normal and pathological gene expression programs in immune cells.
Alizadeh, Arash Ash.

Genome-scale characterization of normal and pathological gene expression programs in immune cells. - 203 p.

Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2005.

Thesis (Ph.D.)--Stanford University, 2003.

The ability to simultaneously study thousands of genes has revolutionized several areas of molecular biology and medicine. We set out to use this new technology to study human cells of the hematopoetic lineage. To this end, we created the Lymphochip, a custom cDNA microarray enriched for genes relevant to the biology of immune cells. We also created SOURCE, a unified resource serving as a publicly available reference for the structural and functional annotation of genes. We used these tools to study the response of normal and malignant immune cells to a variety of physiological and nonphysiological conditions. Distinct features of these expression programs were identified, and have helped elucidate the complex signaling networks in human T-lymphocytes, host responses to bacterial infections, mechanisms of lymphomagenesis, and have allowed molecular classification of known classes of tumors. In addition, these results have surprisingly demonstrated that a group of tumors previously considered to be one entity in fact consists of two classes of tumor, with important clinical consequences.Subjects--Topical Terms:

1017730
Biology, Genetics.

Genome-scale characterization of normal and pathological gene expression programs in immune cells.
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100 1 $a Alizadeh, Arash Ash. $3 1948394
245 1 0 $a Genome-scale characterization of normal and pathological gene expression programs in immune cells.
300 $a 203 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2005.
500 $a Adviser: Patrick O. Brown.
502 $a Thesis (Ph.D.)--Stanford University, 2003.
520 $a The ability to simultaneously study thousands of genes has revolutionized several areas of molecular biology and medicine. We set out to use this new technology to study human cells of the hematopoetic lineage. To this end, we created the Lymphochip, a custom cDNA microarray enriched for genes relevant to the biology of immune cells. We also created SOURCE, a unified resource serving as a publicly available reference for the structural and functional annotation of genes. We used these tools to study the response of normal and malignant immune cells to a variety of physiological and nonphysiological conditions. Distinct features of these expression programs were identified, and have helped elucidate the complex signaling networks in human T-lymphocytes, host responses to bacterial infections, mechanisms of lymphomagenesis, and have allowed molecular classification of known classes of tumors. In addition, these results have surprisingly demonstrated that a group of tumors previously considered to be one entity in fact consists of two classes of tumor, with important clinical consequences.
590 $a School code: 0212.
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650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Engineering, Biomedical. $3 1017684
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