東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Exploration of functional sites in c...

Banatao, Diosdado Rey.

FindBook

Google Book

Amazon

博客來

Exploration of functional sites in complex RNA folds and macromolecular assemblies.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Exploration of functional sites in complex RNA folds and macromolecular assemblies./
作者:	Banatao, Diosdado Rey.
面頁冊數:	158 p.
附註:	Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1615.
Contained By:	Dissertation Abstracts International64-04B.
標題:	Biology, Molecular. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3088632

Exploration of functional sites in complex RNA folds and macromolecular assemblies.
Banatao, Diosdado Rey.

Exploration of functional sites in complex RNA folds and macromolecular assemblies. - 158 p.

Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1615.

Thesis (Ph.D.)--University of California, San Francisco, 2003.

Structural genomics efforts enable the high-throughput discovery of novel molecular structures and are quickly outpacing traditional biochemical methods for determining the function of those molecules. This flood of structural data has created the need for rapid and automated ways to annotate function to molecular structures. Additionally, the interest in RNA structure and function has increased rapidly within the past several years, as dramatic discoveries have been made about novel biological mechanisms directly involving RNA. The folding, structure, and function of all RNA molecules are dependent on the direct and indirect coordination of magnesium (Mg<super>2+</super>) ions. However, locating Mg<super>2+</super> binding sites is difficult experimentally and computationally. Thus, in my doctoral research, I have created and applied computational tools to address issues in the identification of functional sites in RNA structures and assemblies. I developed a novel approach, based on a previous method of identifying functional sites in protein structures, for understanding and locating Mg<super>2+</super> binding sites in RNA. I have developed additional tools for the integrated analysis and visualization of my results with RNA structure. I have also contributed to the development of a generally applicable tool for knowledge modeling and structural modeling of the ribosome, the large assembly of RNA and proteins responsible for protein synthesis in the cell. I have successfully validated this approach on experimentally characterized RNA systems and have demonstrated that it is scalable to the analysis of large RNA assemblies. Most importantly, I have identified novel Mg<super>2+</super> binding sites that may have important functional roles in RNA catalysis, especially in ribosomal activity. I provided detailed descriptions of these sites that may guide experimentalists in the comprehensive analysis of Mg<super>2+</super> binding in RNA and the ribosome. My methods and discoveries may serve as tools for rational drug design targeting RNA and its assemblies.Subjects--Topical Terms:

1017719
Biology, Molecular.

Exploration of functional sites in complex RNA folds and macromolecular assemblies.
LDR:02933nmm 2200265 4500 001 1859351
005 20041014084349.5
008 130614s2003 eng d
035 $a (UnM)AAI3088632
035 $a AAI3088632
040 $a UnM $c UnM
100 1 $a Banatao, Diosdado Rey. $3 1947011
245 1 0 $a Exploration of functional sites in complex RNA folds and macromolecular assemblies.
300 $a 158 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-04, Section: B, page: 1615.
502 $a Thesis (Ph.D.)--University of California, San Francisco, 2003.
520 $a Structural genomics efforts enable the high-throughput discovery of novel molecular structures and are quickly outpacing traditional biochemical methods for determining the function of those molecules. This flood of structural data has created the need for rapid and automated ways to annotate function to molecular structures. Additionally, the interest in RNA structure and function has increased rapidly within the past several years, as dramatic discoveries have been made about novel biological mechanisms directly involving RNA. The folding, structure, and function of all RNA molecules are dependent on the direct and indirect coordination of magnesium (Mg<super>2+</super>) ions. However, locating Mg<super>2+</super> binding sites is difficult experimentally and computationally. Thus, in my doctoral research, I have created and applied computational tools to address issues in the identification of functional sites in RNA structures and assemblies. I developed a novel approach, based on a previous method of identifying functional sites in protein structures, for understanding and locating Mg<super>2+</super> binding sites in RNA. I have developed additional tools for the integrated analysis and visualization of my results with RNA structure. I have also contributed to the development of a generally applicable tool for knowledge modeling and structural modeling of the ribosome, the large assembly of RNA and proteins responsible for protein synthesis in the cell. I have successfully validated this approach on experimentally characterized RNA systems and have demonstrated that it is scalable to the analysis of large RNA assemblies. Most importantly, I have identified novel Mg<super>2+</super> binding sites that may have important functional roles in RNA catalysis, especially in ribosomal activity. I provided detailed descriptions of these sites that may guide experimentalists in the comprehensive analysis of Mg<super>2+</super> binding in RNA and the ribosome. My methods and discoveries may serve as tools for rational drug design targeting RNA and its assemblies.
590 $a School code: 0034.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biophysics, General. $3 1019105
650 4 $a Computer Science. $3 626642
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0307
690 $a 0786
690 $a 0984
690 $a 0419
710 2 0 $a University of California, San Francisco. $3 1025118
773 0 $t Dissertation Abstracts International $g 64-04B.
790 $a 0034
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3088632