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Manipulating and measuring the physi...

D'Onofrio, Terrence Gregory.

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Manipulating and measuring the physical properties and local structure of biomembranes.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Manipulating and measuring the physical properties and local structure of biomembranes./
Author:	D'Onofrio, Terrence Gregory.
Description:	159 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3294.
Contained By:	Dissertation Abstracts International64-07B.
Subject:	Chemistry, Physical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3098227

Manipulating and measuring the physical properties and local structure of biomembranes.
D'Onofrio, Terrence Gregory.

Manipulating and measuring the physical properties and local structure of biomembranes. - 159 p.

Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3294.

Thesis (Ph.D.)--The Pennsylvania State University, 2003.

Local composition, structure, morphology, and phase are interrelated in lipid bilayer membranes. This gives us the opportunity to control one or more of these properties by manipulating others. These properties are important in biology for endocytosis and exocytosis, lipid raft formation, and lateral diffusion of membrane-bound species. We discuss methods of preparing two-component/two-phase giant unilamellar vesicles as models for biological membranes and we detail the development of tools to measure and to control the properties of these membranes. We investigate these relationships with combinations of simultaneous two-color widefield fluorescence imaging, three-dimensional rendering of vesicle domains, and manipulation of the vesicle morphology and measurement of the material properties via micropipette aspiration. We demonstrate microtubule degradation induced by free radicals that penetrate the membrane. Such systematic measurements are critical in understanding the roles of individual membrane components and their aggregate effects on the behavior of the whole system.Subjects--Topical Terms:

560527
Chemistry, Physical.

Manipulating and measuring the physical properties and local structure of biomembranes.
LDR:01967nmm 2200265 4500 001 1858972
005 20041020095008.5
008 130614s2003 eng d
035 $a (UnM)AAI3098227
035 $a AAI3098227
040 $a UnM $c UnM
100 1 $a D'Onofrio, Terrence Gregory. $3 1946639
245 1 0 $a Manipulating and measuring the physical properties and local structure of biomembranes.
300 $a 159 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-07, Section: B, page: 3294.
500 $a Adviser: Paul S. Weiss.
502 $a Thesis (Ph.D.)--The Pennsylvania State University, 2003.
520 $a Local composition, structure, morphology, and phase are interrelated in lipid bilayer membranes. This gives us the opportunity to control one or more of these properties by manipulating others. These properties are important in biology for endocytosis and exocytosis, lipid raft formation, and lateral diffusion of membrane-bound species. We discuss methods of preparing two-component/two-phase giant unilamellar vesicles as models for biological membranes and we detail the development of tools to measure and to control the properties of these membranes. We investigate these relationships with combinations of simultaneous two-color widefield fluorescence imaging, three-dimensional rendering of vesicle domains, and manipulation of the vesicle morphology and measurement of the material properties via micropipette aspiration. We demonstrate microtubule degradation induced by free radicals that penetrate the membrane. Such systematic measurements are critical in understanding the roles of individual membrane components and their aggregate effects on the behavior of the whole system.
590 $a School code: 0176.
650 4 $a Chemistry, Physical. $3 560527
650 4 $a Biophysics, General. $3 1019105
690 $a 0494
690 $a 0786
710 2 0 $a The Pennsylvania State University. $3 699896
773 0 $t Dissertation Abstracts International $g 64-07B.
790 1 0 $a Weiss, Paul S., $e advisor
790 $a 0176
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3098227