東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

RNA affinity and specificity of modi...

Luedtke, Nathan William.

Linked to FindBook

Google Book

Amazon

博客來

RNA affinity and specificity of modified aminoglycosides, metal complexes, and intercalating agents that target the HIV-1 rev response element (Immune deficiency).

Record Type:	Electronic resources : Monograph/item
Title/Author:	RNA affinity and specificity of modified aminoglycosides, metal complexes, and intercalating agents that target the HIV-1 rev response element (Immune deficiency)./
Author:	Luedtke, Nathan William.
Description:	314 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1231.
Contained By:	Dissertation Abstracts International64-03B.
Subject:	Chemistry, Biochemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3083459

RNA affinity and specificity of modified aminoglycosides, metal complexes, and intercalating agents that target the HIV-1 rev response element (Immune deficiency).
Luedtke, Nathan William.

RNA affinity and specificity of modified aminoglycosides, metal complexes, and intercalating agents that target the HIV-1 rev response element (Immune deficiency). - 314 p.

Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1231.

Thesis (Ph.D.)--University of California, San Diego, 2003.

RNA plays a pivotal role in the replication of all organisms, including viral and bacterial pathogens. The development of small molecules that can selectively interfere with undesired RNA activity is a promising new direction for drug design. Systematic studies of the binding interactions between small molecules and RNA are essential for deciphering the parameters that govern RNA recognition. The synthesis of new ligands with high RNA affinity is relatively easy compared to discovering new ligands with high specificity for the desired RNA target. The RRE affinity and specificity of every small molecule is not necessarily proportional to its anti-HIV activity. Issues related to cellular uptake, localization, and the non-specific binding of other cellular components can dramatically affect the biological activities of small molecules.Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

RNA affinity and specificity of modified aminoglycosides, metal complexes, and intercalating agents that target the HIV-1 rev response element (Immune deficiency).
LDR:01813nmm 2200277 4500 001 1856940
005 20040728104831.5
008 130614s2003 eng d
035 $a (UnM)AAI3083459
035 $a AAI3083459
040 $a UnM $c UnM
100 1 $a Luedtke, Nathan William. $3 1944689
245 1 0 $a RNA affinity and specificity of modified aminoglycosides, metal complexes, and intercalating agents that target the HIV-1 rev response element (Immune deficiency).
300 $a 314 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1231.
500 $a Chair: Yitzhak Tor.
502 $a Thesis (Ph.D.)--University of California, San Diego, 2003.
520 $a RNA plays a pivotal role in the replication of all organisms, including viral and bacterial pathogens. The development of small molecules that can selectively interfere with undesired RNA activity is a promising new direction for drug design. Systematic studies of the binding interactions between small molecules and RNA are essential for deciphering the parameters that govern RNA recognition. The synthesis of new ligands with high RNA affinity is relatively easy compared to discovering new ligands with high specificity for the desired RNA target. The RRE affinity and specificity of every small molecule is not necessarily proportional to its anti-HIV activity. Issues related to cellular uptake, localization, and the non-specific binding of other cellular components can dramatically affect the biological activities of small molecules.
590 $a School code: 0033.
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Chemistry, Organic. $3 516206
650 4 $a Biophysics, General. $3 1019105
690 $a 0487
690 $a 0490
690 $a 0786
710 2 0 $a University of California, San Diego. $3 1018093
773 0 $t Dissertation Abstracts International $g 64-03B.
790 1 0 $a Tor, Yitzhak, $e advisor
790 $a 0033
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3083459