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Advancements in optics-based chemica...

O'Brien, Michael J., II.

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Advancements in optics-based chemical and biosensors with array applications.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Advancements in optics-based chemical and biosensors with array applications./
作者:	O'Brien, Michael J., II.
面頁冊數:	269 p.
附註:	Source: Dissertation Abstracts International, Volume: 63-06, Section: B, page: 2890.
Contained By:	Dissertation Abstracts International63-06B.
標題:	Physics, Optics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3058289
ISBN:	0493734139

Advancements in optics-based chemical and biosensors with array applications.
O'Brien, Michael J., II.

Advancements in optics-based chemical and biosensors with array applications. - 269 p.

Source: Dissertation Abstracts International, Volume: 63-06, Section: B, page: 2890.

Thesis (Ph.D.)--The University of New Mexico, 2002.

Chemical- and biosensor research and development has seen a surge in the last two decades. This work covers the development of new optics-based sensor systems employing surface plasmon resonance (SPR) and frequency-domain lifetime fluorimetry transduction techniques.

ISBN: 0493734139Subjects--Topical Terms:

1018756
Physics, Optics.

Advancements in optics-based chemical and biosensors with array applications.
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245 1 0 $a Advancements in optics-based chemical and biosensors with array applications.
300 $a 269 p.
500 $a Source: Dissertation Abstracts International, Volume: 63-06, Section: B, page: 2890.
500 $a Director: S. R. J. Brueck.
502 $a Thesis (Ph.D.)--The University of New Mexico, 2002.
520 $a Chemical- and biosensor research and development has seen a surge in the last two decades. This work covers the development of new optics-based sensor systems employing surface plasmon resonance (SPR) and frequency-domain lifetime fluorimetry transduction techniques.
520 $a We address the issue of optimizing sensitivity through choice of excitation wavelength in prism-based SPR sensor systems. We provide experimental data illustrating the benefits of using yellow (594.1 nm) laser light with gold films in SPR sensor systems.
520 $a One of the serious issues with SPR sensor measurements is their (unwanted) sensitivity to changes in temperature and solute concentration. We present a new and simple method for compensating for both of these phenomenon with a single, inert reference element in a sensor array.
520 $a Fiber-optic SPR sensor systems have traditionally been difficult to work with, due to instabilities or lack of sensitivity in aqueous environments. We present a single-mode fiber based SPR biosensor (in aqueous environments), using 594.1 nm excitation light. We offer a model for the interactions of a fiber Bragg grating with the plasmon resonance, and provide experimental data obtained using such a system.
520 $a We show a new SPR sensor array platform based on spectroscopic imaging. Our approach crosses one-dimensional microscopy with “fan-type” SPR spectroscopy. We provide several experimental demonstrations of its suitability for biosensor measurements.
520 $a We present a new frequency-domain fluorescence lifetime sensor technique based on an optoelectronic, closed-loop system. The frequency of self-oscillations in this system changes as fluorescence lifetime changes, and is used as the sensing parameter. This new technique offers high sensitivity at low cost.
520 $a Finally, we discuss a unique, 16 channel, fluorescence-lifetime based sensor array platform. This inexpensive system uses single-frequency modulation spectroscopy to monitor the changes in a excited-state lifetimes. We provide several experimental demonstrations of this unit's capability of performing measurements with fluorescence-based sensor arrays.
590 $a School code: 0142.
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