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Synthesis and chemical modification ...

Won, Chee-Youb.

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Synthesis and chemical modification of biodegradable polymers for biomedical applications.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Synthesis and chemical modification of biodegradable polymers for biomedical applications./
作者:	Won, Chee-Youb.
面頁冊數:	123 p.
附註:	Source: Dissertation Abstracts International, Volume: 58-12, Section: B, page: 6609.
Contained By:	Dissertation Abstracts International58-12B.
標題:	Chemistry, Polymer. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9818269
ISBN:	059169848X

Synthesis and chemical modification of biodegradable polymers for biomedical applications.
Won, Chee-Youb.

Synthesis and chemical modification of biodegradable polymers for biomedical applications. - 123 p.

Source: Dissertation Abstracts International, Volume: 58-12, Section: B, page: 6609.

Thesis (Ph.D.)--Cornell University, 1997.

Recently, there are considerable research activities toward the development of synthetic biodegradable polymers for providing better biomaterials for medical applications.

ISBN: 059169848XSubjects--Topical Terms:

1018428
Chemistry, Polymer.

Synthesis and chemical modification of biodegradable polymers for biomedical applications.
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100 1 $a Won, Chee-Youb. $3 1943503
245 1 0 $a Synthesis and chemical modification of biodegradable polymers for biomedical applications.
300 $a 123 p.
500 $a Source: Dissertation Abstracts International, Volume: 58-12, Section: B, page: 6609.
502 $a Thesis (Ph.D.)--Cornell University, 1997.
520 $a Recently, there are considerable research activities toward the development of synthetic biodegradable polymers for providing better biomaterials for medical applications.
520 $a In this dissertation, synthesis of novel biodegradable polymers having pendant amine functional groups and chemical modification of naturally occurring polysaccharides are discussed.
520 $a Chapter 1 describes the synthesis of new biodegradable polyesters based on N-Z-L-aspartic acid anhydride and 1,4-cyclohexanedimethanol by solution polycondensation reaction using p-toluenesulfonic acid as a catalyst. The resulting low molecular weight polymers (M $\ rm\sb{w} $ = 1140-5050) contained amine pendant functional groups to which drugs or biologically active agents could be covalently attached.
520 $a Chapter 2 reports the synthesis and in vitro hydrolytic degradation study of novel biodegradable poly(L-aspartic acid-co-PEG). The high molecular weight copolymer (M $\ rm\sb{w} $ = 31700) was prepared by the melt polycondensation reaction of prepolymer using titanium isopropoxide as a catalyst. The resulting copolymers contained a reactive amine functional groups on the side chain of aspartic acid residue of the copolymers. The hydrolytic degradation of these poly(ether ester)s might be produced by a simple hydrolysis of backbone ester bonds and was characterized by rapid rates of hydrolysis at pH 10.
520 $a Chapter 3 describes a better chemical synthesis than toxic phosgene to modify starch and a new synthetic route to attach hormone, particularly, estrone onto the modified starch. A starch was chemically modified with bromoacetyl bromide to provide more reactive sites for coupling of bioactive estrone and a suitable spacer between the drug carrier and the hormone.
520 $a Chapter 4 presents the preparation of dextran-estrone hormone conjugate and the release pattern of the estrone from the conjugate in vitro. In order to provide a suitable reactive estrone derivative for its coupling with dextran biopolymer, the estrone was first succinylated by reacting with succinic anhydride. Subsequently, the carboxylic acid terminal of succinylated estrone was further reacted with thionyl chloride to prepare estrone-3-hemisuccinic acid chloride. In vitro release studies of the dextran-estrone conjugate showed that the estrone hormone was completely released within a few days and followed a linear relationship with time, i.e. zero order. This promising preliminary results may represent a new approach in the steroids therapy.
520 $a Chapter 5 demonstrates the esterification of inulin with N-protected lysine and glycine by the DCC/DMAP method under mild conditions. A study of the deprotection of N-protected amino acids bound to inulin was also investigated by the method of catalytic hydrogenation.
590 $a School code: 0058.
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0495
690 $a 0541
710 2 0 $a Cornell University. $3 530586
773 0 $t Dissertation Abstracts International $g 58-12B.
790 $a 0058
791 $a Ph.D.
792 $a 1997
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9818269