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The effect of whole-body cooling on ...

Mermier, Christine Mariam.

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The effect of whole-body cooling on physical performance in patients with generalized myasthenia gravis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The effect of whole-body cooling on physical performance in patients with generalized myasthenia gravis./
Author:	Mermier, Christine Mariam.
Description:	120 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2468.
Contained By:	Dissertation Abstracts International64-06B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3093055

The effect of whole-body cooling on physical performance in patients with generalized myasthenia gravis.
Mermier, Christine Mariam.

The effect of whole-body cooling on physical performance in patients with generalized myasthenia gravis. - 120 p.

Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2468.

Thesis (Ph.D.)--The University of New Mexico, 2003.

Myasthenia gravis (MG) is an autoimmune disorder caused by antibodies that disrupt the nicotinic post-synaptic acetylcholine receptors (AChRs) at the neuromuscular junction of skeletal muscle. Loss of these receptors leads to a defect in neuromuscular transmission causing muscle weakness and fatigue. Several studies since 1974 have demonstrated the influence of temperature on neuromuscular transmission in MG. Borenstein & Desmedt (1974) showed that local warming of muscles tested via repetitive nerve stimulation aggravates the neuromuscular failure and increases the decrement and postactivation exhaustion, while cooling showed a dramatic improvement in myasthenic failure even with small changes in temperature. To date, no study has been done to determine the effects of a lowered whole-body temperature on the ability to perform exercise on patients with myasthenia gravis. The purpose of this study was to determine if cooler body temperatures could improve muscular strength and endurance, subjective perceptions of weakness and fatigue, and respiratory muscle strength in patients with generalized myasthenia gravis.Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

The effect of whole-body cooling on physical performance in patients with generalized myasthenia gravis.
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008 130614s2003 eng d
035 $a (UnM)AAI3093055
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040 $a UnM $c UnM
100 1 $a Mermier, Christine Mariam. $3 1943414
245 1 0 $a The effect of whole-body cooling on physical performance in patients with generalized myasthenia gravis.
300 $a 120 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-06, Section: B, page: 2468.
500 $a Co-Chairs: Len Kravitz; Suzanne Schneider.
502 $a Thesis (Ph.D.)--The University of New Mexico, 2003.
520 $a Myasthenia gravis (MG) is an autoimmune disorder caused by antibodies that disrupt the nicotinic post-synaptic acetylcholine receptors (AChRs) at the neuromuscular junction of skeletal muscle. Loss of these receptors leads to a defect in neuromuscular transmission causing muscle weakness and fatigue. Several studies since 1974 have demonstrated the influence of temperature on neuromuscular transmission in MG. Borenstein & Desmedt (1974) showed that local warming of muscles tested via repetitive nerve stimulation aggravates the neuromuscular failure and increases the decrement and postactivation exhaustion, while cooling showed a dramatic improvement in myasthenic failure even with small changes in temperature. To date, no study has been done to determine the effects of a lowered whole-body temperature on the ability to perform exercise on patients with myasthenia gravis. The purpose of this study was to determine if cooler body temperatures could improve muscular strength and endurance, subjective perceptions of weakness and fatigue, and respiratory muscle strength in patients with generalized myasthenia gravis.
520 $a The sample consisted of six patients (5 females, 1 male), aged 29–58 years with diagnosed generalized MG. Three trials were completed, two control trials in ambient temperature (NT) to assess day-to-day variability of the measurements, and one cold temperature trial (CT). Isokinetic muscle strength and endurance of the wrist and shoulder, and grip strength were measured. Measurement of Myasthenic Muscle Score (MMS) was used to assess muscle impairment and weakness specific to MG. Pulmonary function measurements included forced vital capacity (FVC) and maximal inspiratory (MIP) and expiratory (MEP) pressures. A subjective scale of fatigue impact (FIS) was administered throughout the testing. Core body temperature was recorded using an ingestible CorTemp<super> ®</super> thermometer pill (Cor-100, HTI Technologies, Palmetto, FL.) with an ambulatory recorder/data logger (BCTM3, PED Inc., v1.08, Southborough, MA) for continuous measurement and recording of temperature transmitted by the sensor pill. Surface electrodes were placed at four sites for measurement of skin temperature. Mean body temperature was calculated using a weighted sum of the core temperature and average skin temperature using the following equation: °C = (0.35Tskin) + (0.65Tcore). During the cooling trial, subjects wore lightweight clothing underneath a fitted liquid cooling garment.
520 $a Wilcoxon signed rank test was used to analyze differences between the two control conditions. Because there were no significant differences between the two NT conditions, all data were averaged and combined for a single NT score. Subsequently, a Wilcoxon signed rank test was run to analyze differences between the cooled and combined control conditions. A simple regression analysis was used to examine the relationship between core temperature (Tc) and %BF for both CT and NT.
520 $a Mean body temperature (0.65core + 0.35skin) was significantly different (p = 0.043) between the NT and CT trials (mean temp. = 35.76 and 34.96°C, respectively). The MMS and MIP showed significant differences, p = 0.030, and p = 0.028, respectively. All other variables were not statistically different between temperature conditions. Individual results of several tests resulted in four to five out of six subjects showing improvement with the CT. These included grip strength of the fight hand, fatique ratio for wrist extensors and shoulder internal and external rotators, FVC, and MEP.
590 $a School code: 0142.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Recreation. $3 1018003
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Biology, Neuroscience. $3 1017680
690 $a 0433
690 $a 0575
690 $a 0573
690 $a 0317
710 2 0 $a The University of New Mexico. $3 1018024
773 0 $t Dissertation Abstracts International $g 64-06B.
790 1 0 $a Kravitz, Len, $e advisor
790 1 0 $a Schneider, Suzanne, $e advisor
790 $a 0142
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3093055