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Molecular and genetic characterizati...

French, Rachael Louise.

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Molecular and genetic characterization of the function of tramtrack in dorsal appendage morphogenesis in Drosophila melanogaster.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Molecular and genetic characterization of the function of tramtrack in dorsal appendage morphogenesis in Drosophila melanogaster./
Author:	French, Rachael Louise.
Description:	146 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0523.
Contained By:	Dissertation Abstracts International64-02B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3079217

Molecular and genetic characterization of the function of tramtrack in dorsal appendage morphogenesis in Drosophila melanogaster.
French, Rachael Louise.

Molecular and genetic characterization of the function of tramtrack in dorsal appendage morphogenesis in Drosophila melanogaster. - 146 p.

Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0523.

Thesis (Ph.D.)--University of Washington, 2003.

The Drosophila gene <italic>tramtrack</italic> (<italic>ttk</italic>) encodes two transcriptional repressors, Ttk69 and Ttk88, which are required for normal embryogenesis and imaginal disc development. Here I characterize a novel female sterile allele of <italic>tramtrack</italic> called <italic> twin peaks</italic> (<italic>ttk<super>twk</super></italic>) that, unlike other <italic>tramtrack</italic> alleles, has no effect on viability and produces no obvious morphological defects, except during oogenesis. Females homozygous for <italic>twin peaks</italic> produce small eggs with thin eggshells and short dorsal respiratory appendages. Complementation analyses, immunolocalization and rescue data demonstrate that these defects are due to loss of Ttk69, which is expressed in the follicle cells and is required for normal chorion production and dorsal follicle cell migration. Analyses of phenotypes produced by mutations in other loci that regulate eggshell synthesis suggest that the chorion production and follicle cell migration defects are independent. I present evidence that <italic> twin peaks</italic> disrupts a promoter or promoters required for late-stage follicle cell expression of Ttk69. I hypothesize that loss of Ttk69 in all follicle cells disrupts chorion gene expression and lack of function in dorsal anterior follicle cells inhibits morphogenetic changes required for elongating the dorsal appendages.Subjects--Topical Terms:

1017730
Biology, Genetics.

Molecular and genetic characterization of the function of tramtrack in dorsal appendage morphogenesis in Drosophila melanogaster.
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035 $a (UnM)AAI3079217
035 $a AAI3079217
040 $a UnM $c UnM
100 1 $a French, Rachael Louise. $3 1942992
245 1 0 $a Molecular and genetic characterization of the function of tramtrack in dorsal appendage morphogenesis in Drosophila melanogaster.
300 $a 146 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-02, Section: B, page: 0523.
500 $a Chair: Celeste A. Berg.
502 $a Thesis (Ph.D.)--University of Washington, 2003.
520 $a The Drosophila gene <italic>tramtrack</italic> (<italic>ttk</italic>) encodes two transcriptional repressors, Ttk69 and Ttk88, which are required for normal embryogenesis and imaginal disc development. Here I characterize a novel female sterile allele of <italic>tramtrack</italic> called <italic> twin peaks</italic> (<italic>ttk<super>twk</super></italic>) that, unlike other <italic>tramtrack</italic> alleles, has no effect on viability and produces no obvious morphological defects, except during oogenesis. Females homozygous for <italic>twin peaks</italic> produce small eggs with thin eggshells and short dorsal respiratory appendages. Complementation analyses, immunolocalization and rescue data demonstrate that these defects are due to loss of Ttk69, which is expressed in the follicle cells and is required for normal chorion production and dorsal follicle cell migration. Analyses of phenotypes produced by mutations in other loci that regulate eggshell synthesis suggest that the chorion production and follicle cell migration defects are independent. I present evidence that <italic> twin peaks</italic> disrupts a promoter or promoters required for late-stage follicle cell expression of Ttk69. I hypothesize that loss of Ttk69 in all follicle cells disrupts chorion gene expression and lack of function in dorsal anterior follicle cells inhibits morphogenetic changes required for elongating the dorsal appendages.
520 $a To investigate the mechanism by which Ttk69 regulates dorsal appendage morphogenesis, I conducted a screen for mutations that dominantly suppress the ttk dorsal appendage phenotype. I recovered eight mutations that suppressed the dorsal appendage defect, as well as two enhancers of the weak chorion phenotype. Among the suppressors, I identified <italic>vegetable</italic> (<italic>veg</italic>), which encodes a novel seven-pass transmembrane protein that is required for PNS development, and <italic>Ggamma1</italic> (<italic> Gγ1</italic>), the gamma subunit of a heterotrimeric G protein. Together, these data implicate G protein coupled receptor signaling in dorsal appendage morphogenesis.
590 $a School code: 0250.
650 4 $a Biology, Genetics. $3 1017730
690 $a 0369
710 2 0 $a University of Washington. $3 545923
773 0 $t Dissertation Abstracts International $g 64-02B.
790 1 0 $a Berg, Celeste A., $e advisor
790 $a 0250
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3079217