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An investigation of single-site ener...

Jiang, Lihong.

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An investigation of single-site energetics and dynamics in nucleic acids by NMR spectroscopy.

Record Type:	Electronic resources : Monograph/item
Title/Author:	An investigation of single-site energetics and dynamics in nucleic acids by NMR spectroscopy./
Author:	Jiang, Lihong.
Description:	219 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1130.
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3084707

An investigation of single-site energetics and dynamics in nucleic acids by NMR spectroscopy.
Jiang, Lihong.

An investigation of single-site energetics and dynamics in nucleic acids by NMR spectroscopy. - 219 p.

Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1130.

Thesis (Ph.D.)--Wesleyan University, 2003.

This thesis describes an investigation of dynamics and stability of individual base pairs in nucleic acid structures using nuclear magnetic resonance (NMR) spectroscopy.

An investigation of single-site energetics and dynamics in nucleic acids by NMR spectroscopy.
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008 130614s2003 eng d
035 $a (UnM)AAI3084707
035 $a AAI3084707
040 $a UnM $c UnM
100 1 $a Jiang, Lihong. $3 1942203
245 1 0 $a An investigation of single-site energetics and dynamics in nucleic acids by NMR spectroscopy.
300 $a 219 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1130.
500 $a Adviser: Irina M. Russu.
502 $a Thesis (Ph.D.)--Wesleyan University, 2003.
520 $a This thesis describes an investigation of dynamics and stability of individual base pairs in nucleic acid structures using nuclear magnetic resonance (NMR) spectroscopy.
520 $a The first part of the thesis describes the characterization of dynamics and stability of individual base pairs in a few nucleic acid structures using proton exchange. We have investigated three intramolecular triple-helical structures: a triple helix that contains only canonical YRY base triads [5<super> ′</super>-d(AGAGAGAA-CCCC-TTCTCTCT-TTT-TCTCTCTT)-3<super>′</super>], an YRY triple helix that contains one non-canonical GTA base triad [5<super> ′</super>-d(AGA<bold>T</bold>AGAA-CCCC-TTCT<bold>A</bold>TCT-TATA-TCT<bold> G</bold>TCTT)-3<super>′</super>] and a triple helix that contains canonical RRY triads: [5<super>′</super>-d(TCCTCCT-TTTTT-AGGAGGA-TTTTT-TGGTGGT)-3<super> ′</super>]. For the canonical YRY triple helix, we have demonstrated the existence of enthalpy-entropy compensation in imino proton exchange and we have analyzed the energetic origin of this phenomenon. For the non-canonical YRY triple helix we have characterized the stability of the non-canonical GTA base triad and the energetic effects of this base triad upon the stability of canonical base triads in the triple helix. For the RRY triplex, we have found that formation of the triple-helical structure stabilizes the Watson-Crick double helix less effectively than for the YRY triple helix
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3084707